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Benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine: biological activities and dental care applications.
This article reviews chemical, pharmacological, and toxicological research relating to two principal benzo[c]phenanthridine alkaloids, namely sanguinarine and chelerythrine, in the period 1980-1994.…
New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid
Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status.
Effect of quaternary benzo[c]phenanthridine alkaloids sanguilutine and chelilutine on normal and cancer cells.
Structure of Chelerythrine Base
The structure of chelerythrine free base was examined. When chelerythrine chloride [1b] was treated with aqueous K2CO3 solution, bis[6-(5,6-dihydrochelerythrinyl)] ether  was obtained. An excess…
On the nature of the so-called methoxychelidonine.
The so-called methoxychelidonine, an alkaloid isolated in 1924 from Chelidonium majus L. ( Papaveraceae ), is not an individual compound, but a mixture of three related alkaloids (+)-chelamine ( III…
Essentials of Medical Chemistry and Biochemistry
The English text has been created for one-semester course of medical chemistry. It is assigned for the students of English program of General medicine and Dentistry studies. The textbook summarizes…
Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells
- I. Slaninová, E. Táborská, H. Bochořáková, J. Slanina
- Chemistry, BiologyCell Biology and Toxicology
The strongest effects of sanguinarine were explained as a consequence of its easy penetration through the cell membrane owing to nonpolar pseudobase formation and to a high degree of molecular planarity.
Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties
- H. Bochořáková, H. Paulová, J. Slanina, P. Musil, E. Táborská
- Chemistry, BiologyPhytotherapy research : PTR
- 1 June 2003
It was concluded, that the scavenging activity of the extract against DPPH is mainly derived from baicalin, and baical in, wogonin glucuronide and probably other flavonoids participate in scavenging OH radical.
Antitumour activities of sanguinarine and related alkaloids
- I. Slaninová, K. Pěnčíková, J. Urbanová, J. Slanina, E. Táborská
- Biology, ChemistryPhytochemistry Reviews
- 1 March 2014
This review summarises the current state of knowledge about the properties of QBAs that are important for their potential use in anticancer therapy and describes Sanguinarine as a best-known member of this group.