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mycothiol biosynthetic process

Known as: mycothiol formation, mycothiol synthesis, mycothiol anabolism 
The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D… Expand
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Redox control in actinobacteria.
As most actinobacteria are obligate aerobes, they have to cope with endogenously generated reactive oxygen species, and… Expand
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Highly Cited
2008
Highly Cited
2008
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis
Spontaneous mutants of Mycobacterium tuberculosis that were resistant to the anti‐tuberculosis drugs ethionamide and isoniazid… Expand
Highly Cited
2006
Highly Cited
2006
Biochemistry of the Initial Steps of Mycothiol Biosynthesis*
Mycothiol is the major thiol produced by mycobacteria and is required for growth of Mycobacterium tuberculosis. The final three… Expand
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Highly Cited
2004
Highly Cited
2004
Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis.
All living species require protection against the damaging effects of the reactive oxygen species that are a natural by-product… Expand
Highly Cited
2003
Highly Cited
2003
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).
Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2… Expand
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Highly Cited
2002
Highly Cited
2002
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes
Abstract. Mycothiol is the predominant thiol in most actinomycetes, including Mycobacterium tuberculosis, and appears to play a… Expand
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Highly Cited
2002
Highly Cited
2002
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases.
Mycothiol is a novel thiol produced only by actinomycetes and is the major low molecular weight thiol in mycobacteria. The… Expand
Review
2002
Review
2002
Mycothiol biochemistry
Abstract. Mycothiol (MSH) is a novel thiol comprised of N-acetylcysteine amide-linked to GlcN-α(1–1)-Ins. It is the major thiol… Expand
Highly Cited
2000
Highly Cited
2000
N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.
Mycothiol is a novel thiol produced only by actinomycetes and is the major low-molecular-weight thiol in mycobacteria. Mycothiol… Expand
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Highly Cited
1999
Highly Cited
1999
Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis.
Mycothiol (MSH) is the major low molecular weight thiol in mycobacteria. Two chemical mutants with low MSH and one with no MSH… Expand
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