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mycothiol biosynthetic process

Known as: mycothiol formation, mycothiol synthesis, mycothiol anabolism 
The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D… Expand
National Institutes of Health

Papers overview

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2009
2009
Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.
We identified the first enzymes that use mycothiol and mycoredoxin in a thiol/disulfide redox cascade. The enzymes are two… Expand
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Highly Cited
2008
Highly Cited
2008
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis
Spontaneous mutants of Mycobacterium tuberculosis that were resistant to the anti-tuberculosis drugs ethionamide and isoniazid… Expand
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2008
2008
Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA.
Mycothiol (MSH) is the major thiol in Actinobacteria and plays a role analogous to that of glutathione. The biosynthetic pathway… Expand
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2006
2006
The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum.
Data mining of the Corynebacterium glutamicum genome identified 4 genes analogous to the mshA, mshB, mshC, and mshD genes that… Expand
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2006
2006
Biochemistry of the initial steps of mycothiol biosynthesis.
Mycothiol is the major thiol produced by mycobacteria and is required for growth of Mycobacterium tuberculosis. The final three… Expand
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2004
2004
Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis.
All living species require protection against the damaging effects of the reactive oxygen species that are a natural by-product… Expand
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2003
2003
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).
Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2… Expand
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Review
2002
Review
2002
Mycothiol biochemistry
Abstract. Mycothiol (MSH) is a novel thiol comprised of N-acetylcysteine amide-linked to GlcN-α(1–1)-Ins. It is the major thiol… Expand
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2002
2002
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes
Abstract. Mycothiol is the predominant thiol in most actinomycetes, including Mycobacterium tuberculosis, and appears to play a… Expand
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1999
1999
Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis.
Mycothiol (MSH) is the major low molecular weight thiol in mycobacteria. Two chemical mutants with low MSH and one with no MSH… Expand
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