• Publications
  • Influence
RsrA, an anti‐sigma factor regulated by redox change
TLDR
A redox‐sensitive, σR‐specific anti‐sigma factor, RsrA, is identified, which binds ρR and inhibits σG‐directed transcription in vitro only under reducing conditions and correlated with intramolecular disulfide bond formation in £rA. Expand
A reducing system of the superoxide sensor SoxR in Escherichia coli
TLDR
Electron paramagnetic resonance analysis of SoxR and measurement of re‐reduction kinetics support the proposal that rsx and rseC gene products constitute a reducing system for SoxR. Expand
Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP‐1 transcriptional regulation
TLDR
Yeast mutants deleted for GLR1, encoding glutathione reductase, lack GLR activity and accumulate increased levels of GSSG, indicating a requirement forGLR in protection against oxidative stress. Expand
IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe‐S assembly proteins
TLDR
Results support a model that IscR in its demetallated form directly activates sufA transcription, while it de‐represses isc operon, under oxidative stress condition. Expand
A novel nickel-containing superoxide dismutase from Streptomyces spp.
TLDR
The apoenzymes, lacking in nickel, had no ability to mediate the conversion of superoxide anion radical to hydrogen peroxide, strongly indicating that NiIII plays a main role in these enzymes. Expand
Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur
TLDR
A crystal structure of active Zur from Streptomyces coelicolor with three zinc-binding sites is presented, showing that zinc chelation by TPEN derepressed some genes more sensitively than others in vivo and enabled bacteria to detect metal depletion with improved sensitivity and optimize gene-expression pattern. Expand
A master regulator σB governs osmotic and oxidative response as well as differentiation via a network of sigma factors in Streptomyces coelicolor
TLDR
The results support a hypothesis that σB serves as a master regulator that triggers other related sigma factors in a cascade, and thus regulates differentiation and osmotic and oxidative response in S. coelicolor. Expand
Mutational analysis of RsrA, a zinc‐binding anti‐sigma factor with a thiol–disulphide redox switch
TLDR
It is proposed that a thiol–disulphide redox switch is formed between two of C11, C41 and C44, and that all three residues play an essential role in anti‐sigma factor activity in their reduced state, perhaps by acting as ligands for zinc. Expand
The Escherichia coli glucose transporter enzyme IICBGlc recruits the global repressor Mlc
TLDR
A general mechanism for glucose induction of gene expression in E.coli is elucidated, revealing a novel type of regulatory circuit for gene expression mediated by the phosphorylation state‐dependent interaction of a membrane‐bound protein with a repressor. Expand
Induction of the sufA operon encoding Fe‐S assembly proteins by superoxide generators and hydrogen peroxide: involvement of OxyR, IHF and an unidentified oxidant‐responsive factor
TLDR
It is proposed that the oxidant induction of the sufA operon is mediated through OxyR, IHF, plus an unidentified oxidant‐responsive factor, and that thesuf gene products are needed to defend cells against oxidative stress caused by superoxide generators. Expand
...
1
2
3
4
5
...