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mycolic acid biosynthetic process

Known as: mycolic acid anabolism, mycolic acid biosynthesis, mycolic acid synthesis 
The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. [GOC… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Delamanid (OPC-67683), a nitro-dihydro-imidazooxazole derivative, is a new antituberculosis medication that inhibits… Expand
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Highly Cited
2009
Highly Cited
2009
Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its… Expand
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Highly Cited
2005
Highly Cited
2005
Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2. GroEL2 is essential--presumably providing the… Expand
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Highly Cited
2003
Highly Cited
2003
ABSTRACT Ethionamide (ETH) is a structural analog of the antituberculosis drug isoniazid (INH). Both of these drugs target InhA… Expand
Highly Cited
2003
Highly Cited
2003
Mycolic acids are major and specific constituents of the cell envelope of Corynebacterineae, a suborder of bacterial species… Expand
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Highly Cited
2000
Highly Cited
2000
The anti-tuberculosis drug ethionamide (ETH), which is a structural analog of isoniazid (INH), is known to strongly inhibit… Expand
Highly Cited
2000
Highly Cited
2000
ABSTRACT The mechanism of action of isoniazid (INH), a first-line antituberculosis drug, is complex, as mutations in at least… Expand
Highly Cited
1998
Highly Cited
1998
The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an… Expand
Highly Cited
1995
Highly Cited
1995
The inhA gene has been recently shown to encode a common protein target for isoniazid and ethionamide action in Mycobacterium… Expand
Highly Cited
1970
Highly Cited
1970
SUMMARY Exposure of growing Mycobacterium tuberculosis BCG to 1 μg. isoniazid/ml. inhibited the incorporation of 14C from [U-14C… Expand
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