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mycolic acid biosynthetic process

Known as: mycolic acid anabolism, mycolic acid biosynthesis, mycolic acid synthesis 
The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. [GOC… 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections.
Mycobacterium abscessus is a fast-growing, multidrug-resistant organism that has emerged as a clinically significant pathogen in… 
2014
2014
Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis
Mycolic acids (MAs) are α‐alkyl, β‐hydroxy long‐chain fatty acids found in abundance in the cell envelope of the Mycobacterium… 
2006
2006
Predicted highly expressed genes in Nocardia farcinica and the implication for its primary metabolism and nocardial virulence
AbstractNocardia farcinica is a Gram positive, filamentous bacterium, and is considered an opportunistic pathogen. In this study… 
2006
2006
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.
Highly Cited
2004
Highly Cited
2004
Catalase-peroxidases (KatG) Exhibit NADH Oxidase Activity*
Catalase-peroxidases (KatG) produced by Burkholderia pseudomallei, Escherichia coli, and Mycobacterium tuberculosis catalyze the… 
2004
2004
Novel heteroarotinoids as potential antagonists of Mycobacterium bovis BCG.
A series of 15 heteroarotinoids has been prepared and evaluated for activity against Mycobacterium bovis BCG with the thiourea… 
2004
2004
Rational design of new antituberculosis agents: receptor-independent four-dimensional quantitative structure-activity relationship analysis of a set of isoniazid derivatives.
A 4D-QSAR analysis was carried out for a set of 37 hydrazides whose minimum inhibitory concentrations against M. tuberculosis var… 
1996
1996
Determination of the primary target for isoniazid in mycobacterial mycolic acid biosynthesis with Mycobacterium aurum A+.
The target of the potent antituberculosis drug isoniazid was investigated in Mycobacterium aurum A+, against which isoniazid has… 
Highly Cited
1992
Highly Cited
1992
Mycolic acid synthesis: a target for ethionamide in mycobacteria?
Striking structural analogies exist between the two specific antimycobacterial drugs ethionamide (ETH) and isoniazid (INH), and… 
Highly Cited
1991
Highly Cited
1991
Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum
Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both… 
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