mycolic acid biosynthetic process
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Delamanid (OPC-67683), a nitro-dihydro-imidazooxazole derivative, is a new antituberculosis medication that inhibits… Expand Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its… Expand Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2. GroEL2 is essential--presumably providing the… Expand ABSTRACT Ethionamide (ETH) is a structural analog of the antituberculosis drug isoniazid (INH). Both of these drugs target InhA… Expand Mycolic acids are major and specific constituents of the cell envelope of Corynebacterineae, a suborder of bacterial species… Expand The anti-tuberculosis drug ethionamide (ETH), which is a structural analog of isoniazid (INH), is known to strongly inhibit… Expand ABSTRACT The mechanism of action of isoniazid (INH), a first-line antituberculosis drug, is complex, as mutations in at least… Expand The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an… Expand The inhA gene has been recently shown to encode a common protein target for isoniazid and ethionamide action in Mycobacterium… Expand SUMMARY
Exposure of growing Mycobacterium tuberculosis BCG to 1 μg. isoniazid/ml. inhibited the incorporation of 14C from [U-14C… Expand