mycolic acid biosynthetic process

Known as: mycolic acid anabolism, mycolic acid biosynthesis, mycolic acid synthesis 
The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. [GOC… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Delamanid (OPC-67683), a nitro-dihydro-imidazooxazole derivative, is a new antituberculosis medication that inhibits… (More)
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Highly Cited
2009
Highly Cited
2009
Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its… (More)
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Highly Cited
2009
Highly Cited
2009
The bicyclic nitroimidazole PA-824 is a pro-drug with a very complex mechanism of action active against both replicating and… (More)
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Highly Cited
2005
Highly Cited
2005
Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2. GroEL2 is essential--presumably providing the… (More)
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Highly Cited
2004
Highly Cited
2004
The Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis possess several unique and structurally… (More)
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Highly Cited
2004
Highly Cited
2004
Mycolic acids are major and specific constituents of the cell envelope of Corynebacterineae, a suborder of bacterial species… (More)
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Highly Cited
2003
Highly Cited
2003
Mycobacterium tuberculosis infects one-third of the world's population and causes two million deaths annually. The unusually low… (More)
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Highly Cited
2003
Highly Cited
2003
Ethionamide (ETH) is a structural analog of the antituberculosis drug isoniazid (INH). Both of these drugs target InhA, an enzyme… (More)
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Highly Cited
1998
Highly Cited
1998
The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an… (More)
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Highly Cited
1972
Highly Cited
1972
When an actively growing culture of the H37Ra strain of Mycobacterium tuberculosis was exposed to isoniazid at a concentration of… (More)
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