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Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase*
TLDR
To their surprise, 3-MA is found to promote autophagy flux when treated under nutrient-rich conditions with a prolonged period of treatment, whereas it is still capable of suppressing starvation-induced autophagosomes or lysosomal function.
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
TLDR
This work identifies a member of the major facilitator superfamily—Mfsd2a (previously an orphan transporter)—as the major transporter for DHA uptake into brain and reveals an unexpected essential physiological role of plasma-derived LPCs in brain growth and function.
Amphiphysin 2 (Bin1) and T-Tubule Biogenesis in Muscle
TLDR
Findings support a role of the bilayer-deforming properties of amphiphysin at T-tubules and, more generally, a physiological role of amphphysin in membrane deformation.
PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER–plasma membrane contacts
TLDR
Two similar ER integral membrane proteins, oxysterol-binding protein (OSBP)–related protein 5 (ORP5) and ORP8, tethered the ER to the plasma membrane (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (PI4P) in this membrane.
Salmonella Modulates Vesicular Traffic by Altering Phosphoinositide Metabolism
TLDR
SopB, a phosphoinositide phosphatase that is delivered into host cells by a type III secretion system, was essential for the establishment of Salmonella's intracellular replicative niche and was responsible for maintaining high levels of phosphatidylinositol-three-phosphate in the membrane of the bacteria-containing vacuoles.
Retroviruses Human Immunodeficiency Virus and Murine Leukemia Virus Are Enriched in Phosphoinositides
TLDR
Overall, these results suggest that HIV-1 and other retroviruses bud from cholesterol-rich regions of the plasma membrane and exploit matrix/PI(4,5)P2 interactions for particle release from cells.
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
TLDR
The data provide the first evidence for a dual role of a Rab GTPase in regulating both generation and turnover of PIs via PI kinases and phosphatases to coordinate signaling functions with organelle homeostasis.
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
TLDR
It is shown here that TLR4 is an upstream signaling component required for saturated fatty acid-induced ceramide biosynthesis, and that sphingolipids such as ceramide might be key components of the signaling networks that link lipid-induced inflammatory pathways to the antagonism of insulin action that contributes to diabetes.
A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets
TLDR
Results from in vivo and in vitro analyses indicate that PA may facilitate the coalescence of contacting LDs, resulting in the formation of “supersized” LDs.
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