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mycobacidin

Known as: 4-oxo-thiazolidinehexanoic acid, acidomycin, actithiazic acid 
 
National Institutes of Health

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2 relations

Broader (2)

CaproatesThiazolidines

Papers overview

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2019
2019
Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.
The synthesis, absolute stereochemical configuration, complete biological characterization, mechanism of action and resistance… Expand
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2001
2001
Biochemical characterization of the Arabidopsis biotin synthase reaction. The importance of mitochondria in biotin synthesis.
Biotin synthase, encoded by the bio2 gene in Arabidopsis, catalyzes the final step in the biotin biosynthetic pathway. The… Expand
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1994
1994
Improvement of a d-biotin-hyperproducing recombinant strain of Serratia marcescens.
We previously reported that a recombinant strain, SB412(pLGM304), was constructed from acidomycin-resistant mutants of Serratia… Expand
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1993
1993
Biotin biosynthesis in higher plant cells. Identification of intermediates.
Biotin biosynthesis was investigated in lavender cell cultures (Lavandula vera L.). Two different biological assays and two… Expand
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1993
1993
Construction of a Biotin-Overproducing Strain of Serratia marcescens.
We have isolated mutants resistant to acidomycin, a biotin analog, from Serratia marcescens Sr41. Strain SB304, resistant to 0.5… Expand
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1993
1993
Molecular breeding of a biotin-hyperproducing Serratia marcescens strain.
We previously reported that an acidomycin-resistant mutant of Serratia marcescens Sr41, SB304, and a mutant that was derived from… Expand
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1993
1993
Sequencing analysis of mutation points in the biotin operon of biotin-overproducing Escherichia coli mutants.
We analyzed mutation points of the biotin operon from biotin-overproducing mutants of Escherichia coli resistant to two biotin… Expand
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1982
1982
Mode of action of the biotin antimetabolites actithiazic acid and alpha-methyldethiobiotin.
Actithiazic acid and alpha-methyldethiobiotin inhibited the conversion of dethiobiotin to biotin resting-cell suspensions of… Expand
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1975
1975
Biological studies of amiclenomycin.
The action of amiclenomycin (AM) in inhibiting growth of microorganisms is specific against mycobacteria in vitro, but the… Expand
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1958
1958
The effects of actithiazic acid on egg white-induced biotin deficiency and upon the microbial formation of biotin vitamers in the rat.
Abstract Actithiazic acid, an antibiotic known to interfere with the biotin metabolism of certain bacteria, did not significantly… Expand
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