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Identification of an intramitochondrially synthesized proteolipid associated with the mitochondrial ATPase complex as the product of a mitochondrial gene determining oligomycin resistance in
TLDR
An extranuclear oligomycin-resistant mutant of Aspergillus nidulans was isolated and biochemically analyzed and it was concluded that this small lipophilic protein is coded by a mitochondrial gene determining oligomecin resistance, is synthesized on mitochondrial ribosomes and is associated with the membrane sector of the ATPase complex.
Mitochondrial ATPase complex of Aspergillus nidulans and the dicyclohexylcarbodiimide-binding protein.
TLDR
Using a double-labelling technique in the absence and presence of cycloheximide, followed by immunoprecipitation of the enzyme complex with antiserum against Neuospora crassa F1 ATPase, it has been shown that this subunit is synthesized on cytoplasmic ribosomes.
Biological breakdown of benzylpenicillin by preformed mats of penicillin-producing organisms.
TLDR
Penicillium chrysogenum and Aspergillus flavus degraded benzylpenicillin in the same way andCatabolism of valine by the preformed mats of the two moulds confirms this result.
ASK-753, a new iron-containing antibiotic.
TLDR
A new iron-containing peptide which inhibits the growth of Gram-positive and some Gram-negative bacteria was isolated from the broth of Streptomyces AS-K-753, which is similar in many properties to the sideromycin but differs from it in certain crucial characteristics.
Further studies on ASN-136 and monoketo-organomycin cystaurimycin, a broad spectrum substance produced by partial enzymic digestion of monoketo-organomycin.
TLDR
The two antibiotics ASN-136 and monoketo-organomycin showed very close similarities in their UV, IR spectra and elemental analysis to those of tuberactinomycin and yazumycin respectively, which revealed the novelty of the two former antibiotics.
Mechanism of action of monoketo-organomycin, cystaurimycin and their performic acid-oxidized modifications. I. Effects on bacterial growth and ribosomal peptidyl transferase activity.
TLDR
In light of the puromycin reaction, using chloramphenicol and chlorotetracycline as control inhibitors, monoketo-organomycin and cystaurimycin were found to inhibit protein synthesis in vitro by inhibiting peptidyl transferase of ribosomes.
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