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morphine-6-glucuronide

Known as: beta-D-Glucopyranosiduronic acid, (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-yl, morphine 6 glucuronide, morphine-6beta-glucuronide 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Morphine Derivatives Including Cocaine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide.
BACKGROUND Morphine-6-glucuronide (M6G) is a strong µ-receptor agonist with higher affinity than morphine itself. It has been… 
Highly Cited
2003
Highly Cited
2003
Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers
Our objective was to quantify the extent and time course of the effects of morphine‐6‐glucuronide and morphine on pain threshold… 
Review
2001
Review
2001
Morphine-6-Glucuronide
Morphine-6-β-glucuronide (M6G) is an opioid agonist that plays a role in the clinical effects of morphine. Although M6G probably… 
Highly Cited
2000
Highly Cited
2000
Sex Differences in Morphine Analgesia: An Experimental Study in Healthy Volunteers
BackgroundAnimal and human studies indicate the existence of important sex-related differences in opioid-mediated behavior. In… 
Highly Cited
1999
Highly Cited
1999
Retention of heroin and morphine–6β–glucuronide analgesia in a new line of mice lacking exon 1 of MOR–1
Morphine produces analgesia by activating mu opioid receptors encoded by the MOR–1 gene. Although morphine–6β–glucuronide (M6G… 
Highly Cited
1998
Highly Cited
1998
mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality.
Highly Cited
1992
Highly Cited
1992
The analgesic activity of morphine-6-glucuronide.
1. The pharmacokinetics, cardio-respiratory effects and analgesic effects of intravenous morphine-6-glucuronide were studied in… 
Highly Cited
1991
Highly Cited
1991
Mu receptor binding of some commonly used opioids and their metabolites.
Highly Cited
1990
Highly Cited
1990
Morphine-3-glucuronide--a potent antagonist of morphine analgesia.
Highly Cited
1986
Highly Cited
1986
Morphine intoxication in renal failure; the role of morphine-6-glucuronide.
Patients with impaired renal function may experience severe and prolonged respiratory depression when treated with morphine. This… 
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