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Cyclooxygenase‐independent actions of cyclooxygenase inhibitors
Several studies have demonstrated unequivocally that certain nonsteroidal anti‐inflammatory drugs (NSAIDs) such as sodium salicylate, sulindac, ibuprofen, and flurbiprofen cause anti‐inflammatory andExpand
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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essentialExpand
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Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.
Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the activity ofExpand
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Capturing adenylyl cyclases as potential drug targets
Cyclic AMP (cAMP) is an important intracellular signalling mediator. It is generated in mammals by nine membrane-bound and one soluble adenylyl cyclases (ACs), each with distinct regulation andExpand
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COX‐2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX‐2 inhibitor celecoxib
The regular use of various nonsteroidal anti‐inflammatory drugs (NSAIDs) was shown to decrease the incidence of colorectal cancer. This effect is thought to be caused predominantly by inhibition ofExpand
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Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications
Opioids are powerful analgesics but also drugs of abuse. Because opioid addicts are susceptible to certain infections, opioids have been suspected to suppress the immune response. This was supportedExpand
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Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain
Chemotherapy-induced peripheral neuropathic pain (CIPNP)—a severe adverse effect observed in up to 80% of patients during treatment with antineoplastic drugs—limits the tolerable dose of cytostatics,Expand
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Release of algesic substances in human experimental muscle pain
Abstract:Objective: We employed the 'delayed onset of muscle soreness' (DOMS) and the 'hypertonic saline' muscle pain models in combination with muscle microdialysis to evaluate the role ofExpand
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Ziconotide for treatment of severe chronic pain
Pharmacological management of severe chronic pain is difficult to achieve with currently available analgesic drugs, and remains a large unmet therapeutic need. The synthetic peptide ziconotide hasExpand
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Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers
Our objective was to quantify the extent and time course of the effects of morphine‐6‐glucuronide and morphine on pain threshold, pain tolerance, pupil diameter, and side effects.
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