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Cyclooxygenase‐independent actions of cyclooxygenase inhibitors
Differences in cyclooxygenase‐independent mechanisms may have consequences for the specific use of these drugs in individual patients because additional effects may either enhance the efficacy or reduce the toxicity of the respective compounds.
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential
COX‐2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX‐2 inhibitor celecoxib
In vitro and in vivo data indicate that the antitumor effects of celecoxib probably are mediated through COX‐2 independent mechanisms and are not restricted to COX•2 over‐expressing tumors.
Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.
The COx-2-independent molecular targets of these COX-2 inhibitors are described and it is discussed how these targets may be involved in the anticarcinogenic activities of these selective COX -2 inhibitors.
Capturing adenylyl cyclases as potential drug targets
The therapeutic potential of isoform-selective compounds in various clinical settings, including neuropathic pain, neurodegenerative disorders, congestive heart failure, asthma and male contraception are discussed.
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
The correlation of SPHK1 with a poor prognosis as well as its high expression among ER negative tumors are in line with the antiapoptotic and proliferative properties of its product sphingosine-1-phosphate.
Chain length-specific properties of ceramides.
The chain length-specific differences of ceramides including their pathological impact on Alzheimer's disease, inflammation, autophagy, apoptosis and cancer are discussed.
Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications
The present review tries to unravel controversial findings and provides a hypothesis that may help to integrate diverse results that are still unclear whether these properties are mediated through typical opioid receptor activation and inhibitory G-protein-signaling.
Release of algesic substances in human experimental muscle pain
The data support the notion that an inflammatory reaction may be involved in muscle soreness following eccentric exercise, whereas the injection of hypertonic saline into the muscle probably directly stimulates muscle nociceptors and causes glutamate release.
Ziconotide for treatment of severe chronic pain
An overview of the benefits and limitations of intrathecal ziconotide treatment is provided and potential future developments in this new drug class of selective N-type voltage-sensitive calcium-channel blockers are reviewed.