Cyclooxygenase‐independent actions of cyclooxygenase inhibitors
Differences in cyclooxygenase‐independent mechanisms may have consequences for the specific use of these drugs in individual patients because additional effects may either enhance the efficacy or reduce the toxicity of the respective compounds.
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential…
COX‐2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX‐2 inhibitor celecoxib
- S. Grösch, I. Tegeder, E. Niederberger, L. Bräutigam, G. Geisslinger
- Biology, MedicineThe FASEB Journal
- 1 December 2001
In vitro and in vivo data indicate that the antitumor effects of celecoxib probably are mediated through COX‐2 independent mechanisms and are not restricted to COX•2 over‐expressing tumors.
Capturing adenylyl cyclases as potential drug targets
- S. Pierre, T. Eschenhagen, G. Geisslinger, K. Scholich
- BiologyNature reviews. Drug discovery
- 1 April 2009
The therapeutic potential of isoform-selective compounds in various clinical settings, including neuropathic pain, neurodegenerative disorders, congestive heart failure, asthma and male contraception are discussed.
Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.
- S. Grösch, T. Maier, S. Schiffmann, G. Geisslinger
- Biology, MedicineJournal of the National Cancer Institute
- 7 June 2006
The COx-2-independent molecular targets of these COX-2 inhibitors are described and it is discussed how these targets may be involved in the anticarcinogenic activities of these selective COX -2 inhibitors.
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
The correlation of SPHK1 with a poor prognosis as well as its high expression among ER negative tumors are in line with the antiapoptotic and proliferative properties of its product sphingosine-1-phosphate.
Chain length-specific properties of ceramides.
Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain
- M. Sisignano, R. Baron, K. Scholich, G. Geisslinger
- Biology, MedicineNature Reviews Neurology
- 1 December 2014
The failure of previously tested antioxidants, neuroprotective agents, anticonvulsants and antidepressants as therapeutic or preventative strategies are discussed, and individualized, mechanism-based therapeutic options for CIPNP associated with each of the three main drug groups are suggested.
COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites.
Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications
The present review tries to unravel controversial findings and provides a hypothesis that may help to integrate diverse results that are still unclear whether these properties are mediated through typical opioid receptor activation and inhibitory G-protein-signaling.