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monoclonal antibody BEC2

Known as: Anti-idiotypic Monoclonal Antibody BEC2, anti-idiotypic murine monoclonal antibody BEC2, BEC-2 
A murine anti-idiotypic monoclonal antibody (anti-Id MoAb) that is directed against an idiotype mimicking a disialoganglioside GD3. GD3 represents a… Expand
National Institutes of Health

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Monoclonal Antibodies

Papers overview

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2014
2014
Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies
Multiple myeloma (MM) is characterized by the monoclonal expansion of malignant plasma cells in the bone marrow (BM) and the… Expand
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2011
2011
Dimeric IVIG contains natural anti-Siglec-9 autoantibodies and their anti-idiotypes.
BACKGROUND Intravenous immunoglobulin (IVIG) preparations are increasingly used for the treatment of autoimmune and chronic… Expand
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2007
2007
Idiotypic Immune Networks in Mobile-Robot Control
Jerne's idiotypic-network theory postulates that the immune response involves interantibody stimulation and suppression, as well… Expand
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Review
2003
Review
2003
Vaccinating against GD3 ganglioside using BEC2 anti-idiotypic monoclonal antibody.
GD3, a ganglioside expressed on tumors of neuroectodermal origin such as melanoma and small-cell lung carcinoma (SCLC), is an… Expand
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Highly Cited
1999
Highly Cited
1999
Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin.
Despite active therapies for small cell lung cancer (SCLC), most patients relapse and die of the disease. The present study… Expand
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1999
1999
New ether-à-go-go K(+) channel family members localized in human telencephalon.
A cDNA encoding a novel voltage-gated K(+) channel protein was isolated from human brain. This protein, termed BEC1, is 46… Expand
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1996
1996
Immunization of melanoma patients with BEC2 anti-idiotypic monoclonal antibody that mimics GD3 ganglioside: enhanced immunogenicity when combined with adjuvant.
Previous attempts to immunize melanoma patients against GD3 ganglioside have been unsuccessful because of the poor immunogenicity… Expand
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Review
1996
Review
1996
Common infections, idiotypic dysregulation, autoantibody spread and induction of autoimmune diseases.
A new theory to explain the pathogenesis of autoimmune diseases is proposed. It is based on the idiotypic network and does not… Expand
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1989
1989
Idiotypic cascades in cancer patients treated with monoclonal antibody CO17-1A.
We have previously shown that gastrointestinal cancer patients treated with monoclonal antibody CO17-1A (Ab1) developed anti… Expand
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1988
1988
Human monoclonal anti-idiotypic antibodies. I. Establishment of immortalized cell lines from a tumor patient treated with mouse monoclonal antibodies.
Patients who undergo immunotherapy with a murine anti-colon carcinoma mAb (mAb17-1A) generate high titers of anti-idiotype and… Expand
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