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monoclonal antibody BEC2
Known as:
Anti-idiotypic Monoclonal Antibody BEC2
, anti-idiotypic murine monoclonal antibody BEC2
, BEC-2
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A murine anti-idiotypic monoclonal antibody (anti-Id MoAb) that is directed against an idiotype mimicking a disialoganglioside GD3. GD3 represents a…
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National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Monoclonal Antibodies
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Idiotypic Immune Networks in Mobile-Robot Control
Amanda M. Whitbrook
,
U. Aickelin
,
J. Garibaldi
IEEE Transactions on Systems, Man, and…
2007
Corpus ID: 2400466
Jerne's idiotypic-network theory postulates that the immune response involves interantibody stimulation and suppression, as well…
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Highly Cited
2005
Highly Cited
2005
Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of…
G. Giaccone
,
C. Debruyne
,
+10 authors
C. Legrand
Journal of clinical oncology : official journal…
2005
Corpus ID: 11384239
PURPOSE Bec2 is an anti-idiotypic antibody that mimics GD3, a ganglioside that is expressed on the surface of tumor cells and is…
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Review
2003
Review
2003
Vaccinating against GD3 ganglioside using BEC2 anti-idiotypic monoclonal antibody.
P. Chapman
Current opinion in investigational drugs
2003
Corpus ID: 39806825
GD3, a ganglioside expressed on tumors of neuroectodermal origin such as melanoma and small-cell lung carcinoma (SCLC), is an…
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Highly Cited
1999
Highly Cited
1999
Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin.
S. Grant
,
M. Kris
,
A. Houghton
,
P. Chapman
Clinical cancer research : an official journal of…
1999
Corpus ID: 17796798
Despite active therapies for small cell lung cancer (SCLC), most patients relapse and die of the disease. The present study…
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Highly Cited
1996
Highly Cited
1996
Immunization of melanoma patients with BEC2 anti-idiotypic monoclonal antibody that mimics GD3 ganglioside: enhanced immunogenicity when combined with adjuvant.
M. McCaffery
,
T. J. Yao
,
L. Williams
,
P. Livingston
,
A. Houghton
,
P. Chapman
Clinical cancer research : an official journal of…
1996
Corpus ID: 17491917
Previous attempts to immunize melanoma patients against GD3 ganglioside have been unsuccessful because of the poor immunogenicity…
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Review
1996
Review
1996
Common infections, idiotypic dysregulation, autoantibody spread and induction of autoimmune diseases.
Y. Shoenfeld
Journal of autoimmunity
1996
Corpus ID: 23365283
A new theory to explain the pathogenesis of autoimmune diseases is proposed. It is based on the idiotypic network and does not…
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Highly Cited
1989
Highly Cited
1989
Idiotypic cascades in cancer patients treated with monoclonal antibody CO17-1A.
M. Wettendorff
,
D. Iliopoulos
,
+4 authors
D. Herlyn
Proceedings of the National Academy of Sciences…
1989
Corpus ID: 25713094
We have previously shown that gastrointestinal cancer patients treated with monoclonal antibody CO17-1A (Ab1) developed anti…
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1988
1988
Human monoclonal anti-idiotypic antibodies. I. Establishment of immortalized cell lines from a tumor patient treated with mouse monoclonal antibodies.
M. Steinitz
,
S. Tamir
,
J. E. Frödin
,
A. Lefvert
,
H. Mellstedt
Journal of immunology
1988
Corpus ID: 33056716
Patients who undergo immunotherapy with a murine anti-colon carcinoma mAb (mAb17-1A) generate high titers of anti-idiotype and…
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Highly Cited
1984
Highly Cited
1984
Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors.
M. Sy
,
Adam Lowy
,
+4 authors
B. Benacerraf
Proceedings of the National Academy of Sciences…
1984
Corpus ID: 1234223
Prolonged treatment of mice, starting at birth, with rabbit anti-mouse mu-chain antibodies resulted in the elimination of…
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Highly Cited
1974
Highly Cited
1974
CLONAL NATURE OF THE IMMUNE RESPONSE TO PHOSPHORYLCHOLINE
J. L. Claflin
,
J. Davie
The Journal of experimental medicine
1974
Corpus ID: 8737645
A new idiotypic determinant(s) on mouse anti-PC antibodies is described. Antibodies to the determinant(s) were raised in rabbits…
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