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monoclonal antibody BEC2

Known as: Anti-idiotypic Monoclonal Antibody BEC2, anti-idiotypic murine monoclonal antibody BEC2, BEC-2 
A murine anti-idiotypic monoclonal antibody (anti-Id MoAb) that is directed against an idiotype mimicking a disialoganglioside GD3. GD3 represents a… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Jerne's idiotypic-network theory postulates that the immune response involves interantibody stimulation and suppression, as well… Expand
Highly Cited
2005
Highly Cited
2005
PURPOSE Bec2 is an anti-idiotypic antibody that mimics GD3, a ganglioside that is expressed on the surface of tumor cells and is… Expand
Review
2003
Review
2003
  • P. Chapman
  • Current opinion in investigational drugs
  • 2003
  • Corpus ID: 39806825
GD3, a ganglioside expressed on tumors of neuroectodermal origin such as melanoma and small-cell lung carcinoma (SCLC), is an… Expand
Highly Cited
1999
Highly Cited
1999
Despite active therapies for small cell lung cancer (SCLC), most patients relapse and die of the disease. The present study… Expand
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Highly Cited
1996
Highly Cited
1996
Previous attempts to immunize melanoma patients against GD3 ganglioside have been unsuccessful because of the poor immunogenicity… Expand
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Review
1996
Review
1996
A new theory to explain the pathogenesis of autoimmune diseases is proposed. It is based on the idiotypic network and does not… Expand
Highly Cited
1989
Highly Cited
1989
We have previously shown that gastrointestinal cancer patients treated with monoclonal antibody CO17-1A (Ab1) developed anti… Expand
1988
1988
Patients who undergo immunotherapy with a murine anti-colon carcinoma mAb (mAb17-1A) generate high titers of anti-idiotype and… Expand
Highly Cited
1984
Highly Cited
1984
Prolonged treatment of mice, starting at birth, with rabbit anti-mouse mu-chain antibodies resulted in the elimination of… Expand
Highly Cited
1974
Highly Cited
1974
A new idiotypic determinant(s) on mouse anti-PC antibodies is described. Antibodies to the determinant(s) were raised in rabbits… Expand
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