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p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation
The stress‐responsive p38 MAPK, when activated by genotoxic stresses such as UV radiation, enhances p53 activity by phosphorylation and leads to cell cycle arrest or apoptosis. Here we report that a… Expand
Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation.
- M. Itoh, M. Adachi, H. Yasui, M. Takekawa, H. Tanaka, K. Imai
- Medicine, Biology
- Molecular endocrinology
- 1 October 2002
The c-Jun N-terminal kinase (JNK) phosphorylates the glucocorticoid receptor (GR) and inhibits GR-mediated transcription. However, the biological effect of the GR phosphorylation remains unknown.… Expand
Clinical and pathological differences between Mikulicz's disease and Sjögren's syndrome.
OBJECTIVE Mikulicz's disease (MD) has been included within the diagnosis of primary Sjögren's syndrome (SS), but represents a unique condition involving enlargement of the lachrymal and salivary… Expand
A New Function of Green Tea: Prevention of Lifestyle‐related Diseases
- N. Sueoka, M. Suganuma, +5 authors H. Fujiki
- Annals of the New York Academy of Sciences
- 1 April 2001
Abstract: In the normal human life span, there occur lifestyle‐related diseases that may be preventable with nontoxic agents. This paper deals with the preventive activity of green tea in some… Expand
Mechanistic findings of green tea as cancer preventive for humans.
- H. Fujiki, M. Suganuma, +5 authors S. Kimura
- Proceedings of the Society for Experimental…
- 1 April 1999
Based on our initial work with green tea, in which repeated topical applications of (-)-epigallocatechin gallate (EGCG), the main green tea polyphenol, inhibited tumor promotion in a two-stage… Expand
Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis
Histone deacetylase (HDAC) inhibitors modify transcription of selected genes and eventually induce apoptosis. However, molecular mechanisms for their proapoptotic activity remain unclear. We here… Expand
Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers
BACKGROUND/AIM Matrilysin is one of the matrix metalloproteinases that has a critical role in tumour invasion, and is often expressed in gastrointestinal cancers. The aim of this study was to examine… Expand
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.
- H. Yamamoto, F. Itoh, +6 authors K. Imai
- Journal of clinical oncology : official journal…
- 15 February 2001
PURPOSE A disruption in the balance between the matrix metalloproteinases (MMPs) and their natural inhibitors, tissue inhibitors of metalloproteinases (TIMPs), has been implicated in the progression… Expand
Elevated IgG4 concentrations in serum of patients with Mikulicz's disease
Mikulicz's disease has recently been included within primary Sjögren's syndrome. It is a unique condition involving enlargement of the lacrimal and salivary glands, characterized by few autoimmune… Expand
Clinical analysis of results of a simple left atrial procedure for chronic atrial fibrillation.
- K. Imai, T. Sueda, K. Orihashi, M. Watari, Y. Matsuura
- The Annals of thoracic surgery
- 1 February 2001
BACKGROUND We have performed a simple left atrial procedure for eliminating chronic atrial fibrillation (AF) associated with mitral valve disease. This article analyzes the midterm results of this… Expand