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mocimycin

Known as: delvomycin, kirromycin 
National Institutes of Health

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Anti-Bacterial AgentsPyridones

Papers overview

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2008
2008
Sequential asymmetric polyketide heterocyclization catalyzed by a single cytochrome P450 monooxygenase (AurH).
Complex polyketide metabolites, such as macrolides, polyenes, and polyethers, are an important source of novel therapeutics or… 
2005
2005
A mutant elongation factor Tu which does not immobilize the ribosome upon binding of kirromycin.
In the accompanying paper we have shown that polypeptide synthesis sustained by the mutant elongation factor EF-TuBO is inhibited… 
2005
2005
Energetic aspects of the EF-Tu-dependent GTPase activity. A study using the antibiotic kirromycin.
Kirromycin induces a GTPase activity dependent on elongation factor Tu (EF-Tu) in the absence of the normally required aminoacyl… 
1986
1986
Characterization of the elongation factors from calf brain. 2. Functional properties of EF-1 alpha, the action of physiological ligands and kirromycin.
The properties of EF-1 alpha from calf brain have been investigated and compared with those of EF-Tu. EF-1 alpha binds GDP and… 
1985
1985
A second tRNA binding site on elongation factor Tu is induced while the factor is bound to the ribosome.
Previously, we reported that the antibiotic kirromycin induces two tRNA-binding sites on the elongation factor Tu. The classical… 
Highly Cited
1984
Highly Cited
1984
Cross-linking of tRNA at two different sites of the elongation factor Tu.
Recently, we reported on the induction by kirromycin of two tRNA binding sites on elongation factor Tu. To obtain independent… 
1981
1981
Two elongation factors from the extremely halophilic archaebacterium Halobacterium cutirubrum. Assay systems and purification at high salt concentrations.
Two peptide chain elongation factors from Halobacterium cutirubrum were purified nearly to homogeneity. They were identified and… 
1980
1980
Elongation factor Tu isolated from Escherichia coli mutants altered in TufA and tufB.
In a previous paper we described a number of Escherichia coli mutants resistant to the antibiotic kirromycin. These mutants are… 
Highly Cited
1978
Highly Cited
1978
Modification of elongation-factor-Tu . guanine-nucleotide interaction by kirromycin. A comparison with the effect of aminoacyl-tRNA and elongation factor Ts.
Kirromycin activates functions of elongation factor Tu (EF-Tu) that normally require the presence of specific effectors [Wolf et… 
1977
1977
Conformational alteration of protein synthesis elongation factor EF-Tu by EF-Ts and by kirromycin.
Alterations of the structure of EF-Tu have been investigated by using the rate of EF-Tu cleavage by trypsin as a conformational… 
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