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mocimycin

Known as: delvomycin, kirromycin 
National Institutes of Health

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2 relations

Broader (2)

Anti-Bacterial AgentsPyridones

Papers overview

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Highly Cited
2015
Highly Cited
2015
Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM
Single particle electron cryomicroscopy (cryo-EM) has recently made significant progress in high-resolution structure… 
Highly Cited
2008
Highly Cited
2008
Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moiety.
Highly Cited
2002
Highly Cited
2002
Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex
The mRNA codon in the ribosomal A-site is recognized by aminoacyl-tRNA (aa-tRNA) in a ternary complex with elongation factor Tu… 
Highly Cited
1999
Highly Cited
1999
The antibiotic micrococcin acts on protein L11 at the ribosomal GTPase centre.
Micrococcin-resistant mutants of Bacillus megaterium that carry mutations affecting ribosomal protein L11 have been characterised… 
Highly Cited
1995
Highly Cited
1995
Codon‐dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome.
The mechanisms by which elongation factor Tu (EF‐Tu) promotes the binding of aminoacyl‐tRNA to the A site of the ribosome and, in… 
Highly Cited
1990
Highly Cited
1990
Binding of tRNA to the ribosomal A and P sites protects two distinct sets of nucleotides in 16 S rRNA.
Highly Cited
1989
Highly Cited
1989
Bovine mitochondrial protein synthesis elongation factors. Identification and initial characterization of an elongation factor Tu-elongation factor Ts complex.
Animal mitochondrial protein synthesis factors elongation factor (EF) Tu and EF-Ts have been purified as an EF-Tu.Ts complex from… 
Review
1985
Review
1985
Mechanism of action of kirromycin-like antibiotics.
Highly Cited
1978
Highly Cited
1978
Modification of elongation-factor-Tu . guanine-nucleotide interaction by kirromycin. A comparison with the effect of aminoacyl-tRNA and elongation factor Ts.
Kirromycin activates functions of elongation factor Tu (EF-Tu) that normally require the presence of specific effectors [Wolf et… 
Highly Cited
1977
Highly Cited
1977
Mechanism of the inhibition of protein synthesis by kirromycin. Role of elongation factor Tu and ribosomes.
We have investigated the mechanism which allows the antibiotic kirromycin to inhibit peptide bond formation by acting on… 
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