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mitonafide

Known as: 2-(2-(dimethylamino)ethyl)-5-nitro-1H-benz(de)isoquinoline-1,3(2H)-dione, N-(2-dimethylaminoethyl)-3-nitro-naphthalimide, N-(2-dimethylaminoethyl)-3-nitronaphthalimide 
 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Antineoplastic AgentsAntiviral AgentsIntercalating AgentsNaphthalimides

Narrower (1)

M 4212

Papers overview

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2016
2016
Visualizing Hydrogen Sulfide in Mitochondria and Lysosome of Living Cells and in Tumors of Living Mice with Positively Charged Fluorescent Chemosensors.
Two fluorescent chemosenors, Mito-HS and Lyso-HS, were rationally designed and synthesized with positive charge at physiological… Expand
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2015
2015
New photostable naphthalimide-based fluorescent probe for mitochondrial imaging and tracking.
Monitoring mitochondria morphological changes temporally and spatially exhibits significant importance for diagnosing, preventing… Expand
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2011
2011
Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics.
Synthesis and anti-melanoma activity of various naphthalimide analogs, rationally modified by introducing isothiocyanate (ITC… Expand
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2009
2009
Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes.
The present study investigated whether combination of resveratrol and 4-amino 1,8 naphthalimide (4-ANI) is effective in the… Expand
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2005
2005
Benzamide and 4-amino 1,8 naphthalimide treatment inhibit telomerase activity by down-regulating the expression of telomerase associated protein and inhibiting the poly(ADP-ribosyl)ation of…
To test the role of poly(ADP-ribose) polymerase on the telomerase activity, we determined the telomerase activity in leukemic… Expand
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Review
2001
Review
2001
Naphthalimides as anti-cancer agents: synthesis and biological activity.
Naphthalimides are a class of compounds with high antitumor activity upon a variety of murine and human tumor cells. These… Expand
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1996
1996
Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.
Mitonafide (4-nitro-benzoisoquinolinedione) and a number of structural analogs were synthesized and studied in order to determine… Expand
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1992
1992
Phase I study of mitonafide in solid tumors
SummaryMitonafide was the first synthetized compound of a new series of 3-nitronaphthalimides with intercalative properties. A… Expand
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1989
1989
Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs.
Treatment of SV40-infected monkey cells with amonafide (benzisoquinolinedione), an intercalative antitumor drug, resulted in… Expand
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1985
1985
Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid.
The metabolism and the mechanism of action of 5-nitro-2-(2-dimethylaminoethyl)-benzo(de) isoquinoline-1,3-dione (mitonafide), a… Expand
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