mitogen-activated protein kinase p38

Known as: Protein Kinase, p38, p38 Mitogen-Activated Protein Kinases, p38 Protein Kinase 
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION… (More)
National Institutes of Health

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1994-2018
020406019942018

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In BloodMAP kinase activityMAP3K8 protein, humanMAPK11 gene
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MAPK14 protein, human

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1936-2019
19401960198020002020
mitogen-activated protein kinase p38
standards characteristics
physiological aspects
stress-activated protein kinase 1
chemical synthesis
MAP kinase activity

Papers overview

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Highly Cited
2002
Highly Cited
2002
Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.
Nuclear factor of activated T cells (NFAT) is implicated in multiple biological processes, including cytokine gene expression… (More)
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Highly Cited
2001
Highly Cited
2001
Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.
The serine/threonine kinase Akt/PKB is a potent regulator of cell survival and has oncogenic transformation potential. Previously… (More)
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Highly Cited
2000
Highly Cited
2000
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.
A tetracycline-regulated reporter system was used to investigate the regulation of cyclooxygenase 2 (Cox-2) mRNA stability by the… (More)
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Highly Cited
2000
Highly Cited
2000
Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.
Eotaxin and other CC chemokines acting via CC chemokine receptor-3 (CCR3) are believed to play an integral role in the… (More)
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Highly Cited
2000
Highly Cited
2000
Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways.
We investigated whether microtubule-interfering agents (MIAs: taxol, colchicine, nocodazole, vinblastine, vincristine, 17-beta… (More)
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Highly Cited
2000
Highly Cited
2000
Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases.
Cardiomyopathy induced by doxorubicin (DOX) has long been a major impediment of clinical applications of this effective… (More)
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Highly Cited
1998
Highly Cited
1998
Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy.
c-Jun N-terminal protein kinase (JNK) and p38, two distinct members of the mitogen-activated protein (MAP) kinase family… (More)
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Highly Cited
1997
Highly Cited
1997
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.
The p38 mitogen-activated protein kinases (MAPK) are activated by cellular stresses and play an important role in regulating gene… (More)
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Highly Cited
1996
Highly Cited
1996
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.
The stress-activated protein kinases JNK and p38 mediate increased gene expression and are activated by environmental stresses… (More)
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Highly Cited
1994
Highly Cited
1994
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.
Mammalian cells respond to endotoxic lipopolysaccharide (LPS) by activation of protein kinase cascades that lead to new gene… (More)
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