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Tpl2/Cot Signals Activate ERK, JNK, and NF-κB in a Cell-type and Stimulus-specific Manner*
TLDR
The data confirm that defects caused by a single mutation may be cell-type and signal-specific and delineate the role of Tpl2 in the transduction of TNF-α signals that activate JNK and NF-κB in MEFs.
Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19
TLDR
Until results of clinical trials for HCQ prophylaxis become available, this study provides actionable information for policymakers to protect HCWs at the forefront of COVID-19 response.
Bacterial exotoxins downregulate cathelicidin (hCAP‐18/LL‐37) and human β‐defensin 1 (HBD‐1) expression in the intestinal epithelial cells
TLDR
It is shown that enteric pathogens suppress LL‐37 and HBD‐1 expression in the intestinal epithelial cells (IECs) with Vibrio cholerae and enterotoxigenic Escherichia coli (ETEC) exerting the most dramatic effects.
Prediction of Interactions between Viral and Host Proteins Using Supervised Machine Learning Methods
TLDR
The proposed SVM-based method can predict large scale interspecies viral-human PPIs and the nature and function of unknown viral proteins, interacting partners of host protein were identified using optimised SVM model.
Tumor Progression Locus-2 Is a Critical Regulator of Pancreatic and Lung Inflammation during Acute Pancreatitis*
TLDR
It is found that Tpl2 ablation markedly reduced pancreatic and lung inflammation in these two dissimilar models of pancreatitis, but it did not alter pancreatic injury/necrosis in either model.
An adhesion protein of Salmonella enterica serovar Typhi is required for pathogenesis and potential target for vaccine development
TLDR
A 27-kDa outer membrane protein (T2544) plays a major role in bacterial adhesion to the host through high-affinity binding to laminin and is described as an adhesion protein of S. Typhi that contributes to bacterial pathogenesis.
cAMP Stringently Regulates Human Cathelicidin Antimicrobial Peptide Expression in the Mucosal Epithelial Cells by Activating cAMP-response Element-binding Protein, AP-1, and Inducible cAMP Early
TLDR
This is the first report of a detailed mechanistic study of inducible cathelicidin expression in the mucosal ECs and describes a novel immunomodulatory function of cAMP.
Identification of infectious disease-associated host genes using machine learning techniques
TLDR
This is the first computational method to identify infectious disease-associated host genes by integrating sequence and protein interaction network features and the results indicated that for small datasets, advanced DNN-based method does not offer significant advantage over the simpler supervised machine learning techniques, such as Support Vector Machine (SVM) or Random Forest (RF).
Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction
TLDR
Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage and indicates that ARCE pretreatment prevents ISO induced depletion of enzymatic antioxidants and apoptosis.
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