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microtubule nucleation

The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule… 
National Institutes of Health

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Broader (1)

Microtubule Polymerization Process
regulation of microtubule nucleation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Microtubule nucleation by γ-tubulin complexes and beyond
In this short review, we give an overview of microtubule nucleation within cells. It is nearly 30 years since the discovery of… 
Review
2006
Review
2006
Microtubule nucleation: gamma-tubulin and beyond.
Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main microtubule (MT)-organizing centers in… 
Highly Cited
2005
Highly Cited
2005
Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function
The centrosome organizes microtubules by controlling nucleation and anchoring processes. In mammalian cells, subdistal appendages… 
Highly Cited
2005
Highly Cited
2005
Insights into microtubule nucleation from the crystal structure of human γ-tubulin
Microtubules are hollow polymers of αβ-tubulin that show GTP-dependent assembly dynamics and comprise a critical part of the… 
Highly Cited
2005
Highly Cited
2005
Reorganization of microtubule nucleation during muscle differentiation.
Skeletal muscle differentiation involves a complete reorganization of the microtubule network. Nearly 20 years ago, Tassin et al… 
Highly Cited
2005
Highly Cited
2005
Fission yeast mto2p regulates microtubule nucleation by the centrosomin-related protein mto1p.
From an insertional mutagenesis screen, we isolated a novel gene, mto2+, involved in microtubule organization in fission yeast… 
Highly Cited
2005
Highly Cited
2005
Centrosomal Microtubule Nucleation Activity Is Inhibited by BRCA1-Dependent Ubiquitination
ABSTRACT In this study we find that the function of BRCA1 inhibits the microtubule nucleation function of centrosomes. In… 
Highly Cited
2000
Highly Cited
2000
Structure of the gamma-tubulin ring complex: a template for microtubule nucleation.
The gamma-tubulin ring complex (gammaTuRC) is a protein complex of relative molecular mass approximately 2.2 x 10(6) that… 
Review
1997
Review
1997
Centrosome-microtubule nucleation.
In many cell types the formation of microtubules from tubulin subunits is initiated at defined nucleation sites at the centrosome… 
Highly Cited
1992
Highly Cited
1992
γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation
γ-TUBULIN is a newly identified member of the tubulin family whose sequence is highly conserved from yeast to man. This minor… 
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