methymycin
National Institutes of Health
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A divergent and highly stereoselective route to 11 glycosylated methymycin analogues has been developed. The key to the success…
Cytochrome P450 enzymes mediate important oxidative processes in biological systems including regio- and stereospecific…
The majority of modular polyketide synthase (PKS) systems which generate unsaturated products do so with trans double bonds…
Picromycin/methymycin synthase (PICS) is a modular polyketide synthase (PKS) that is responsible for the biosynthesis of both 10…
A mutant strain of Streptomyces venezuelae was engineered by deletion of the entire gene cluster related to biosynthesis of the…
In our study of the biosynthesis of D-desosamine in Streptomyces venezuelae, we have cloned and sequenced the entire desosamine…
Novamethymycin (9), a novel macrolide antibiotic, was isolated from Streptomyces venezuelae, the producer of methymycin (4) and…
In a survey of microbial systems capable of generating unusual metabolite structural variability, Streptomyces venezuelae ATCC…