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methyl pyruvate

 
National Institutes of Health

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Pyruvates

Papers overview

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2014
2014
Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis.
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a disease caused by motor neuron degeneration. Recently, a novel SIGMAR1 gene… Expand
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Highly Cited
2013
Highly Cited
2013
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid… Expand
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Highly Cited
2011
Highly Cited
2011
Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.
Tumor cell proliferation requires both growth signals and sufficient cellular bioenergetics. The AMP-activated protein kinase… Expand
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Highly Cited
2009
Highly Cited
2009
Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells.
Activation of poly(ADP-ribose) polymerase-1 (PARP1) has been shown to mediate cell death induced by genotoxic stimuli. The role… Expand
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Highly Cited
2008
Highly Cited
2008
Ceramide starves cells to death by downregulating nutrient transporter proteins.
Ceramide induces cell death in response to many stimuli. Its mechanism of action, however, is not completely understood. Ceramide… Expand
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Highly Cited
2007
Highly Cited
2007
Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells.
OBJECTIVE Genistein, a naturally occurring isoflavenoid abundant in soy products, has anti-neoplastic activity in multiple tumor… Expand
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Highly Cited
2004
Highly Cited
2004
Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response.
Glucose-stimulated insulin secretion is a multistep process dependent on beta-cell metabolic flux. Our previous studies on intact… Expand
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2001
2001
Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP.
The role of mitochondria in stimulus-secretion coupling of pancreatic beta-cells was examined using methyl pyruvate (MP). MP… Expand
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1997
1997
Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell.
The methyl ester of pyruvic acid (methyl pyruvate) stimulated a dose-dependent increase in insulin secretion from isolated… Expand
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1996
1996
Insulinotropic action of methyl pyruvate: enzymatic and metabolic aspects.
The metabolism of methyl pyruvate was compared to that of pyruvate in isolated rat pancreatic islets. Methyl pyruvate was found… Expand
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