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methyl pyruvate

 
National Institutes of Health

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2014
2014
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a disease caused by motor neuron degeneration. Recently, a novel SIGMAR1 gene… Expand
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Highly Cited
2013
Highly Cited
2013
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid… Expand
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Highly Cited
2011
Highly Cited
2011
Tumor cell proliferation requires both growth signals and sufficient cellular bioenergetics. The AMP-activated protein kinase… Expand
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Highly Cited
2009
Highly Cited
2009
Activation of poly(ADP-ribose) polymerase-1 (PARP1) has been shown to mediate cell death induced by genotoxic stimuli. The role… Expand
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Highly Cited
2008
Highly Cited
2008
Ceramide induces cell death in response to many stimuli. Its mechanism of action, however, is not completely understood. Ceramide… Expand
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Genistein, a naturally occurring isoflavenoid abundant in soy products, has anti-neoplastic activity in multiple tumor… Expand
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Highly Cited
2004
Highly Cited
2004
Glucose-stimulated insulin secretion is a multistep process dependent on beta-cell metabolic flux. Our previous studies on intact… Expand
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2001
2001
The role of mitochondria in stimulus-secretion coupling of pancreatic beta-cells was examined using methyl pyruvate (MP). MP… Expand
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1997
1997
The methyl ester of pyruvic acid (methyl pyruvate) stimulated a dose-dependent increase in insulin secretion from isolated… Expand
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1996
1996
The metabolism of methyl pyruvate was compared to that of pyruvate in isolated rat pancreatic islets. Methyl pyruvate was found… Expand
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