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methyl pyruvate

 

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1967-2017
02419672017

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Pyruvates

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Related mentions per year

1937-2018
19401960198020002020
methyl pyruvate
Pyruvates

Papers overview

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2014
2014
Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis.
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a disease caused by motor neuron degeneration. Recently, a novel SIGMAR1 gene… (More)
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Highly Cited
2013
Highly Cited
2013
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid… (More)
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Highly Cited
2011
Highly Cited
2011
Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.
Tumor cell proliferation requires both growth signals and sufficient cellular bioenergetics. The AMP-activated protein kinase… (More)
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Highly Cited
2004
Highly Cited
2004
Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response.
Glucose-stimulated insulin secretion is a multistep process dependent on beta-cell metabolic flux. Our previous studies on intact… (More)
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2002
2002
Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate.
In pancreatic beta-cells, methyl pyruvate is a potent secretagogue and is widely used to study stimulus-secretion coupling. In… (More)
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2001
2001
Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP.
The role of mitochondria in stimulus-secretion coupling of pancreatic beta-cells was examined using methyl pyruvate (MP). MP… (More)
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1997
1997
Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell.
The methyl ester of pyruvic acid (methyl pyruvate) stimulated a dose-dependent increase in insulin secretion from isolated… (More)
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1996
1996
Insulinotropic action of methyl pyruvate: enzymatic and metabolic aspects.
The metabolism of methyl pyruvate was compared to that of pyruvate in isolated rat pancreatic islets. Methyl pyruvate was found… (More)
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1996
1996
Insulinotropic action of methyl pyruvate: secretory, cationic, and biosynthetic aspects.
Methyl pyruvate was found to exert a dual effect on insulin release from isolated rat pancreatic islets. A positive… (More)
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1995
1995
In vitro and in vivo insulinotropic action of methyl pyruvate.
Methyl pyruvate, when tested at a 10mM concentration, caused a rapid and sustained increase of insulin release evoked by either 7… (More)
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