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methyl pyruvate

 
National Institutes of Health

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Pyruvates

Papers overview

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2014
2014
Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis.
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a disease caused by motor neuron degeneration. Recently, a novel SIGMAR1 gene… Expand
Highly Cited
2013
Highly Cited
2013
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid… Expand
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Highly Cited
2011
Highly Cited
2011
Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models
Tumor cell proliferation requires both growth signals and sufficient cellular bioenergetics. The AMP-activated protein kinase… Expand
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Highly Cited
2008
Highly Cited
2008
Ceramide starves cells to death by downregulating nutrient transporter proteins
Ceramide induces cell death in response to many stimuli. Its mechanism of action, however, is not completely understood. Ceramide… Expand
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Highly Cited
2007
Highly Cited
2007
Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells.
OBJECTIVE Genistein, a naturally occurring isoflavenoid abundant in soy products, has anti-neoplastic activity in multiple tumor… Expand
Highly Cited
2004
Highly Cited
2004
Quantitative NAD(P)H/Flavoprotein Autofluorescence Imaging Reveals Metabolic Mechanisms of Pancreatic Islet Pyruvate Response*
Glucose-stimulated insulin secretion is a multistep process dependent on β-cell metabolic flux. Our previous studies on intact… Expand
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Highly Cited
2003
Highly Cited
2003
Aspects of enantioselective heterogeneous catalysis: structure and reactivity of (S)-(-)-1-(1-naphthyl)ethylamine on Pt[111].
The molecular orientation, spatial distribution, and thermal behavior of the powerful chiral catalyst modifier precursor (S… Expand
Highly Cited
2001
Highly Cited
2001
New methyl pyruvate thiosemicarbazones and their copper and zinc complexes: synthesis, characterization, X-ray structures and biological activity.
By reacting thiosemicarbazides substituted on the aminic nitrogen with both alkyl or aryl groups, and methyl pyruvate a new group… Expand
Highly Cited
2000
Highly Cited
2000
C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Carbonyl−Ene Reactions with Glyoxylate and Pyruvate Esters
The C2-symmetric complexes [Cu(S,S)-tert-butylbis(oxazolinyl)](SbF6)2 (2a), its bis(aquo) counterpart [Cu(S,S)-tert-butylbis… Expand
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1996
1996
Insulinotropic action of methyl pyruvate: enzymatic and metabolic aspects.
The metabolism of methyl pyruvate was compared to that of pyruvate in isolated rat pancreatic islets. Methyl pyruvate was found… Expand
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