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methyl diethyldithiocarbamate

Known as: Me-DTC, diethyldithiocarbamate methyl ester, diethylthiocarbamic acid methyl ester 
National Institutes of Health

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3 relations

Broader (2)

DitiocarbEnzyme Inhibitors
analogs & derivatives

Papers overview

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1998
1998
Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation.
Diethyldithiocarbamate methyl ester (DDTC-Me) is a precursorto the formation of S-methyl-N,N-diethylthiolcarbamate sulfoxide, the… 
1995
1995
Characterization of diethyldithiocarbamate methyl ester sulfine as an intermediate in the bioactivation of disulfiram.
Disulfiram is bioactivated through a series of intermediates, ultimately forming S-methyl-N,N-diethylthiolcarbamate sulfoxide… 
1994
1994
NADPH-dependent, regioselective S-oxidation of a thionosulfur- and thioether-containing xenobiotic, diethyldithiocarbamate methyl ester by rat liver microsomes.
The present study describes the NADPH-dependent, regioselective oxidation of diethyldithiocarbamate methyl ester (DDTC-Me), a… 
1993
1993
Bioactivation of S-methyl N,N-diethylthiolcarbamate to S-methyl N,N-diethylthiolcarbamate sulfoxide. Implications for the role of cytochrome P450.
1989
1989
Diethylthiocarbamic acid methyl ester. A potent inhibitor of aldehyde dehydrogenase found in rats treated with disulfiram or diethyldithiocarbamic acid methyl ester.
1989
1989
Inhibition of human erythrocyte and leukocyte aldehyde dehydrogenase activities by diethylthiocarbamic acid methyl ester. An in vivo metabolite of disulfiram.
1989
1989
Diethylthiocarbamic acid methyl ester: a suicide inhibitor of liver aldehyde dehydrogenases?
In summary, the present work suggests the involvement of an irreversible reaction between a nucleophile in the active site of the… 
1986
1986
Rapid and sensitive on-line precolumn purification and high-performance liquid chromatographic assay for disulfiram and its metabolites.
1980
1980
Determination of disulfiram and metabolites from biological fluids by high-performance liquid chromatography.
1978
1978
Disposition kinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram
Following the intravenous infusion of sodium diethyldithiocarbamate to dogs, the disposition kinetics of diethyldithiocarbamate… 
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