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The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the… Expand The bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized… Expand P2X receptors contain 10 conserved cysteines in the extracellular loop. To investigate whether these residues form disulfide… Expand The excitatory neurotransmitter glutamate is removed from the synaptic cleft by several related sodium- and potassium-coupled… Expand Two forms of serotonin transporter (SERT) were prepared with different epitope tags. When co-expressed in HeLa cells, the form… Expand In voltage- and cyclic nucleotide–gated ion channels, the amino-acid loop that connects the S5 and S6 transmembrane domains, is a… Expand The transmembrane topology of the serotonin transporter (SERT) has been examined by measuring the reactivity of selected lysine… Expand P2X receptors are a family of ATP-gated ion channels thought to have intracellular N and C termini and two transmembrane segments… Expand A powerful tool in the study of cloned ion channels is the combined use of site-directed mutagenesis and chemical modification… Expand Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to… Expand