• Publications
  • Influence
Hemodynamic shear stress and its role in atherosclerosis.
Atherosclerosis, the leading cause of death in the developed world and nearly the leading cause in the developing world, is associated with systemic risk factors including hypertension, smoking,Expand
  • 2,721
  • 134
The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast.
Overexpression of the Arabidopsis thaliana vacuolar H+-pyrophosphatase (AVP1) confers salt tolerance to the salt-sensitive ena1 mutant of Saccharomyces cerevisiae. Suppression of salt sensitivityExpand
  • 554
  • 58
Drought- and salt-tolerant plants result from overexpression of the AVP1 H+-pump
  • R. Gaxiola, J. Li, +4 authors G. Fink
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 September 2001
Transgenic plants overexpressing the vacuolar H+-pyrophosphatase are much more resistant to high concentrations of NaCl and to water deprivation than the isogenic wild-type strains. These transgenicExpand
  • 604
  • 52
Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS)
A simple method for antigen retrieval in tissue sections and cell cultures is described. Because many antibodies recognize denatured proteins on western blots, but are poorly reactive byExpand
  • 216
  • 27
Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase.
The cellular distributions of the kidney form of the erythrocyte band 3 chloride/bicarbonate exchanger and the kidney vacuolar H+-transporting ATPase were examined in rat kidney collecting duct byExpand
  • 327
  • 20
A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1
Ciliary delivery of polycystin-1 depends on a conserved (K/R/Q)VxPx motif. The signal enables Arf4 GTPase binding and assembly of a multimeric trafficking complex. Functional importance of Arf4 andExpand
  • 97
  • 16
Activation of Cell-Specific Transcription by a Serine Phosphatase at the Site of Asymmetric Division
Cell fate is determined by cell-specific activation of transcription factor σF after asymmetric division during sporulation by Bacillus subtilis. The activity of σF is governed by SpoIIAA, SpoIIAB,Expand
  • 234
  • 15
Molecular physiology and genetics of Na+-independent SLC4 anion exchangers
  • S. Alper
  • Medicine, Biology
  • Journal of Experimental Biology
  • 1 June 2009
SUMMARY Plasmalemmal Cl–/HCO3– exchangers are encoded by the SLC4 and SLC26 gene superfamilies, and function to regulate intracellular pH, [Cl–] and cell volume. The Cl–/HCO3– exchangers of polarizedExpand
  • 166
  • 15
Molecular physiology of SLC4 anion exchangers
  • S. Alper
  • Medicine, Biology
  • Experimental physiology
  • 1 January 2006
Plasmalemmal Cl−–HCO3− exchangers regulate intracellular pH and [Cl−] and cell volume. In polarized epithelial cells, they contribute also to transepithelial secretion and reabsorption of acid–baseExpand
  • 195
  • 13
Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes.
Mutations in the human SLC26A3 gene, also known as down-regulated in adenoma (hDRA), cause autosomal recessive congenital chloride-losing diarrhoea (CLD). hDRA expressed in Xenopus oocytes mediatedExpand
  • 153
  • 13