• Publications
  • Influence
Hemodynamic shear stress and its role in atherosclerosis.
TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.
The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast.
TLDR
The regulation of AtNHX1 by NaCl and the ability of the plant gene to suppress the yeast nhx1 mutant suggest that the mechanism by which cations are detoxified in yeast and plants may be similar.
Drought- and salt-tolerant plants result from overexpression of the AVP1 H+-pump
TLDR
The phenotypes of the AVP1 transgenic plants suggest that increasing the vacuolar proton gradient results in increased solute accumulation and water retention, and sequestration of cations in the vacUole reduces their toxic effects.
Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase.
TLDR
Results demonstrate the coexpression of H+-ATPase and band 3 in opposite plasma membrane domains of a subpopulation of intercalated cells that are probably the acid-excreting (type A) cells and probably include the bicarbonate-exCreting ( type B) cells.
Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS)
TLDR
Results show that SDS treatment can be used as a simple method of antigen retrieval in cryostat sections and on cultured cells, and in some cases, antigens were not detectable without pretreatment with SDS.
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.
TLDR
Findings provide direct evidence that R2456H and R2488Q mutations in PIEZO1 alter mechanosensitive channel regulation, leading to increased cation transport in erythroid cells.
A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1
TLDR
The studies offer the first unifying molecular rationale for human cystic kidney diseases and retinopathies.
Molecular physiology and genetics of Na+-independent SLC4 anion exchangers
  • S. Alper
  • Biology
    Journal of Experimental Biology
  • 1 June 2009
TLDR
A growing body of structure–function and interaction data, together with emerging information about physiological function and structure, is advancing the understanding of SLC4 anion exchangers.
Molecular physiology of SLC4 anion exchangers
  • S. Alper
  • Biology
    Experimental physiology
  • 1 January 2006
TLDR
A growing body of structure–function data, together with increased structural information, will advance mechanistic understanding of SLC4 anion exchangers.
Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes
TLDR
Despite the absence of hDRA transcripts in human cell lines derived from CFTR patients, DRA mRNA was present at wild‐type levels in proximal colon and nearly so in the distal ileum of CFTR(‐/‐) mice, suggesting pharmacological modulation of DRA might be a useful adjunct treatment of cystic fibrosis.
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