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metallopeptidase activity

Known as: metalloprotease activity, metalloproteinase activity 
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in… 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
A Staphylococcus aureus Pore-Forming Toxin Subverts the Activity of ADAM10 to Cause Lethal Infection
Staphylococcus aureus is a major cause of human disease, responsible for half a million infections and approximately 20,000… 
Highly Cited
2008
Highly Cited
2008
ADAM10 Regulates Endothelial Permeability and T-Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin
Vascular endothelial (VE)-cadherin is the major adhesion molecule of endothelial adherens junctions. It plays an essential role… 
Highly Cited
2006
Highly Cited
2006
Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity*
Biometals play an important role in Alzheimer disease, and recent reports have described the development of potential therapeutic… 
Review
2006
Review
2006
Extracellular matrix adaptation of tendon and skeletal muscle to exercise
The extracellular matrix (ECM) of connective tissues enables linking to other tissues, and plays a key role in force transmission… 
Highly Cited
2006
Highly Cited
2006
Toll-Like Receptor 9 Agonists Promote Cellular Invasion by Increasing Matrix Metalloproteinase Activity
Toll-like receptor 9 (TLR9) recognizes microbial DNA. We show here that TLR9 protein is expressed in human breast cancer cells… 
Highly Cited
2001
Highly Cited
2001
Expression of cytokines, inducible nitric oxide synthase, and matrix metalloproteinases in pouchitis: effects of probiotic treatment
OBJECTIVE:The efficacy of probiotic organisms in the treatment of pouchitis has been reported. In the present study, we evaluated… 
Highly Cited
2000
Highly Cited
2000
Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro.
We tested the hypothesis that the inflammatory cytokines can regulate fibroblast extracellular matrix metabolism. Neonatal and… 
Highly Cited
1999
Highly Cited
1999
Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme.
OBJECTIVE To investigate the inhibition of matrix metalloproteinase 1 (MMP-1), MMP-8, and MMP-13 by doxycycline, and to determine… 
Highly Cited
1996
Highly Cited
1996
The YTA10–12 Complex, an AAA Protease with Chaperone-like Activity in the Inner Membrane of Mitochondria
Highly Cited
1996
Highly Cited
1996
Increased matrix metalloproteinase activity and reduced tissue inhibitor of metalloproteinases-1 levels in amniotic fluids from pregnancies complicated by premature rupture of membranes.
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