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metal transporting protein 1
Known as:
ferroportin
, ferroportin1 protein
, solute carrier family 40 (iron-regulated transporter), member 1
Â
Â
Topic mentions per year
Topic mentions per year
1992-2018
0
20
40
60
1992
2018
Related topics
Related topics
1 relation
SLC40A1 gene
Related mentions per year
Related mentions per year
1992-2018
1990
2000
2010
2020
metal transporting protein 1
SLC40A1 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
The molecular mechanism of hepcidin-mediated ferroportin down-regulation.
Ivana De Domenico
,
Diane M Ward
,
+6 authors
Jerry Kaplan
Molecular biology of the cell
2007
Ferroportin (Fpn) is the only known iron exporter in vertebrates. Hepcidin, a peptide secreted by the liver in response to iron…Â
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Highly Cited
2007
Highly Cited
2007
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.
Sara Gardenghi
,
M. Marongiu
,
+15 authors
Stefano Rivella
Blood
2007
Progressive iron overload is the most salient and ultimately fatal complication of beta-thalassemia. However, little is known…Â
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Highly Cited
2005
Highly Cited
2005
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.
A L Donovan
,
Christine A Lima
,
+4 authors
Nancy Catherine Andrews
Cell metabolism
2005
Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release…Â
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Highly Cited
2005
Highly Cited
2005
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.
S A López Rivera
,
Elizabeta Nemeth
,
Victoria Gabayan
,
Miguel A. Lopez
,
Dina Farshidi
,
Tomas Ganz
Blood
2005
Hepcidin is the principal iron regulatory hormone and its overproduction contributes to anemia of inflammation (AI). In vitro…Â
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Highly Cited
2005
Highly Cited
2005
Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin.
Constance Delaby
,
Nathalie Pilard
,
Ana Sofia Gonçalves
,
C. Beaumont
,
François Canonne-Hergaux
Blood
2005
Ferroportin, the only mammalian iron exporter identified to date, is highly expressed in duodenal enterocytes and in macrophages…Â
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Highly Cited
2005
Highly Cited
2005
Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin.
Hal Drakesmith
,
Lisa M. Schimanski
,
+9 authors
Alain R. M. Townsend
Blood
2005
Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder…Â
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Highly Cited
2004
Highly Cited
2004
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.
Elizabeta Nemeth
,
Marie S Tuttle
,
+5 authors
Jerry Kaplan
Science
2004
Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to…Â
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Highly Cited
2003
Highly Cited
2003
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
Martina U. Muckenthaler
,
Cindy N. Roy
,
+5 authors
Matthias W. Hentze
Nature Genetics
2003
Individuals with hereditary hemochromatosis suffer from systemic iron overload due to duodenal hyperabsorption. Most cases arise…Â
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Highly Cited
2001
Highly Cited
2001
Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.
Giuliana Montosi
,
Anne L Donovan
,
+7 authors
Agostino Pietrangelo
The Journal of clinical investigation
2001
Hemochromatosis is a progressive iron overload disorder that is prevalent among individuals of European descent. It is usually…Â
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Highly Cited
2001
Highly Cited
2001
A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis
Omer T. Njajou
,
Norbert Vaessen
,
+9 authors
Peter Heutink
Nature Genetics
2001
Hereditary hemochromatosis (HH) is a very common disorder characterized by iron overload and multi-organ damage. Several genes…Â
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