metal transporting protein 1

Ferroportin (Fpn) is the only known iron exporter in vertebrates. Hepcidin, a peptide secreted by the liver in response to iron… (More)

Progressive iron overload is the most salient and ultimately fatal complication of beta-thalassemia. However, little is known… (More)

Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release… (More)

Hepcidin is the principal iron regulatory hormone and its overproduction contributes to anemia of inflammation (AI). In vitro… (More)

Ferroportin, the only mammalian iron exporter identified to date, is highly expressed in duodenal enterocytes and in macrophages… (More)

Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder… (More)

Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to… (More)

Individuals with hereditary hemochromatosis suffer from systemic iron overload due to duodenal hyperabsorption. Most cases arise… (More)

Hemochromatosis is a progressive iron overload disorder that is prevalent among individuals of European descent. It is usually… (More)

Hereditary hemochromatosis (HH) is a very common disorder characterized by iron overload and multi-organ damage. Several genes… (More)