• Publications
  • Influence
Lymphocyte proliferation is controlled by both iron availability and regulation of iron uptake pathways.
TLDR
Differences in sensitivity to the effects of these agents are influenced by the amount of available transferrin-Fe and differences in the mechanisms that individual lymphocyte cell lines utilize to ensure adequate Fe uptake to support proliferation. Expand
A sensitive photometric assay for alcohol dehydrogenase activity in blood serum.
TLDR
Minutes activities of alcohol dehydrogenase in blood serum can be determined from the fading of the yellow color of p-nitrosodimethylaniline in a recycling reaction, which shows the activity of this aldehyde-like substrate. Expand
Serum-free medium for hybridoma and parental myeloma cell cultivation.
Differences in the interactions of liver alcohol dehydrogenases with probes binding into the substrate pocket.
TLDR
The data presented confirm the existence of three distinct binding sites for these ligands in the substrate pocket of liver alcohol dehydrogenase, which are moderately hydrophobic and that for acridines is rather polar. Expand
Growth-stimulating effect of ferric citrate on hybridoma cells: characterization and relation to transferrin function.
  • J. Kovar
  • Biology, Medicine
  • Hybridoma
  • 1 June 1988
TLDR
Experiments with monoclonal antibody to mouse transferrin receptor demonstrate that the growth-stimulating effect of ferric citrate is not based on the action of residual transferrin or theaction of transferrin secreted by hybridoma cells, specific for iron compounds while other metal trace elements are ineffective. Expand
INHIBITION OF LADH BY BERBERINE AND SOME RELATED ALKALOIDS
SUMMARY The alkaloid berberine inhibits oxidation of ethanol by LADH competitively both towards the substrate and the coenzyme NAD + . Fluorometric and spectrophotometry equilibrium measurementsExpand
The inability of cells to grow in low iron correlates with increasing activity of their iron regulatory protein (IRP)
TLDR
It is hypothesized that the relatively higher bioavailability of nontransferrin iron in LIT cells, over that in HID cells, determines the differing responses observed under low-iron conditions. Expand
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