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mespirenone

Known as: 7alpha-acetylthio-15beta,16beta-methylene-3-oxo-17alpha-pregna-1,4-diene-21,17-carbolactone 
A spironolactone derivative and aldosterone antagonist with diuretic activity. Mespirenone, after in vivo metabolization, inhibits aldosterone… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Spironolactone
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Electrogenic Na+ transport in rat late distal colon by natural and synthetic glucocorticosteroids.
The potency of in vitro-added corticosteroids to stimulate electrogenic Na+absorption ( J Na, the Na+ absorptive short-circuit… Expand
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1994
1994
Development of specific bioluminescent In vitro assays for selecting potential antimineralocorticoids
Efficient antimineralocorticoid selection requires a reliable, discriminating and easy assay for monitoring biological activity… Expand
1993
1993
Synthesis of new 11 beta-substituted spirolactone derivatives. Relationship with affinity for mineralocorticoid and glucocorticoid receptors.
Various steroidal 17-spirolactones substituted in the 11 beta-position were synthesized to study the relationship between the… Expand
1991
1991
Potentiation of angiotensin II-induced drinking by glucocorticoids is a specific glucocorticoid Type II receptor (GR)-mediated event
Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the… Expand
1991
1991
Inhibitory effects of the novel anti-aldosterone compound mespirenone on adrenocortical steroidogenesis in vitro.
Mespirenone (CAS 87952-98-5), the delta 1,2-15 beta, 16 beta-methylene derivative of spironolactone, proved to be a potent and… Expand
1991
1991
Effect of a new mineralocorticoid antagonist mespirenone on aldosterone-induced hypertension.
The effects of the mineralocorticoid antagonist mespirenone on the development and maintenance of aldosterone-induced… Expand
1989
1989
Modulation of angiotensin II binding sites in neuronal cultures by mineralocorticoids.
Previous studies have determined that mineralocorticoid hormones are able to increase the number of angiotensin II (ANG II… Expand
1987
1987
Aldosterone antagonists. 2. New 7 alpha-(acetylthio)-15,16-methylene spirolactones.
Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone were synthesized with the purpose of increasing the… Expand
1987
1987
Pharmacokinetics and metabolism of mespirenone, a new aldosterone antagonist, in rat and cynomolgus monkey.
The pharmacokinetics and metabolism of mespirenone were examined in rat and cynomolgus monkey using the tritiated drug. Following… Expand
1986
1986
Mespirenone and other 15,16-methylene-17-spirolactones, a new type of steroidal aldosterone antagonists.
The ability of a series of 15,16-methylene-spirolactones in comparison to known antimineralocorticoids to inhibit the renal… Expand
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