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mespirenone

Known as: 7alpha-acetylthio-15beta,16beta-methylene-3-oxo-17alpha-pregna-1,4-diene-21,17-carbolactone 
A spironolactone derivative and aldosterone antagonist with diuretic activity. Mespirenone, after in vivo metabolization, inhibits aldosterone… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
The potency of in vitro-added corticosteroids to stimulate electrogenic Na+absorption ( J Na, the Na+ absorptive short-circuit… Expand
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1994
1994
Efficient antimineralocorticoid selection requires a reliable, discriminating and easy assay for monitoring biological activity… Expand
1993
1993
Various steroidal 17-spirolactones substituted in the 11 beta-position were synthesized to study the relationship between the… Expand
1991
1991
Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the… Expand
1991
1991
Mespirenone (CAS 87952-98-5), the delta 1,2-15 beta, 16 beta-methylene derivative of spironolactone, proved to be a potent and… Expand
1991
1991
The effects of the mineralocorticoid antagonist mespirenone on the development and maintenance of aldosterone-induced… Expand
1989
1989
Previous studies have determined that mineralocorticoid hormones are able to increase the number of angiotensin II (ANG II… Expand
1987
1987
Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone were synthesized with the purpose of increasing the… Expand
1987
1987
The pharmacokinetics and metabolism of mespirenone were examined in rat and cynomolgus monkey using the tritiated drug. Following… Expand
1986
1986
The ability of a series of 15,16-methylene-spirolactones in comparison to known antimineralocorticoids to inhibit the renal… Expand