mespirenone

Known as: 7alpha-acetylthio-15beta,16beta-methylene-3-oxo-17alpha-pregna-1,4-diene-21,17-carbolactone

A spironolactone derivative and aldosterone antagonist with diuretic activity. Mespirenone, after in vivo metabolization, inhibits aldosterone…

National Institutes of Health

Papers overview

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1991

The effects of the mineralocorticoid antagonist mespirenone on the development and maintenance of aldosterone-induced…

1991

Structure-activity relationships concerning the steroidal skeleton as well as the C21,17-ring systems could be established while…

1990

A dissertation in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Virginia Commonwealth…

1989

Previous studies have determined that mineralocorticoid hormones are able to increase the number of angiotensin II (ANG II…

1988

In the present study, endocrine-pharmacological profiles of new aldosterone antagonists, 15 beta,16 beta-methylenemexrenone (ZK…

1987

Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone were synthesized with the purpose of increasing the…

1987

The pharmacokinetics and metabolism of mespirenone were examined in rat and cynomolgus monkey using the tritiated drug. Following…

1987

1986