Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 205,819,502 papers from all fields of science
Search
Sign In
Create Free Account
mespirenone
Known as:
7alpha-acetylthio-15beta,16beta-methylene-3-oxo-17alpha-pregna-1,4-diene-21,17-carbolactone
A spironolactone derivative and aldosterone antagonist with diuretic activity. Mespirenone, after in vivo metabolization, inhibits aldosterone…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
2 relations
Broader (1)
Spironolactone
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Antimineralocorticoid 11beta-substituted spirolactones exhibit androgen receptor agonistic activity: a structure function study.
P. Nirdé
,
B. Térouanne
,
N. Gallais
,
C. Sultan
,
G. Auzou
Molecular pharmacology
2001
Corpus ID: 9102058
In humans, spironolactone and mespirenone are well known antimineralocorticoids without C-11beta substituents. These compounds…
Expand
1999
1999
Electrogenic Na+ transport in rat late distal colon by natural and synthetic glucocorticosteroids.
I. Grotjohann
,
J. Schulzke
,
M. Fromm
American journal of physiology. Gastrointestinal…
1999
Corpus ID: 4473318
The potency of in vitro-added corticosteroids to stimulate electrogenic Na+absorption ( J Na, the Na+ absorptive short-circuit…
Expand
1994
1994
Development of specific bioluminescent In vitro assays for selecting potential antimineralocorticoids
N. Jausons-Loffreda
,
P. Balaguer
,
G. Auzou
,
M. Pons
The Journal of Steroid Biochemistry and Molecular…
1994
Corpus ID: 31133435
1993
1993
Synthesis of new 11 beta-substituted spirolactone derivatives. Relationship with affinity for mineralocorticoid and glucocorticoid receptors.
M. Claire
,
H. Faraj
,
G. Grassy
,
A. Aumelas
,
A. Rondot
,
G. Auzou
Journal of medicinal chemistry
1993
Corpus ID: 29463083
Various steroidal 17-spirolactones substituted in the 11 beta-position were synthesized to study the relationship between the…
Expand
1991
1991
Potentiation of angiotensin II-induced drinking by glucocorticoids is a specific glucocorticoid Type II receptor (GR)-mediated event
C. Sumners
,
Tammy R. Gault
,
M. Fregly
Brain Research
1991
Corpus ID: 22975236
1991
1991
Effect of a new mineralocorticoid antagonist mespirenone on aldosterone-induced hypertension.
J. Opoku
,
M. Kalimi
,
M. Agarwal
,
D. Qureshi
The American journal of physiology
1991
Corpus ID: 46499069
The effects of the mineralocorticoid antagonist mespirenone on the development and maintenance of aldosterone-induced…
Expand
1991
1991
Inhibitory effects of the novel anti-aldosterone compound mespirenone on adrenocortical steroidogenesis in vitro.
K. Weindel
,
S. Lewicka
,
P. Vecsei
Arzneimittel-Forschung
1991
Corpus ID: 22657448
Mespirenone (CAS 87952-98-5), the delta 1,2-15 beta, 16 beta-methylene derivative of spironolactone, proved to be a potent and…
Expand
1989
1989
Modulation of angiotensin II binding sites in neuronal cultures by mineralocorticoids.
C. Sumners
,
M. Fregly
The American journal of physiology
1989
Corpus ID: 22426683
Previous studies have determined that mineralocorticoid hormones are able to increase the number of angiotensin II (ANG II…
Expand
1987
1987
Aldosterone antagonists. 2. New 7 alpha-(acetylthio)-15,16-methylene spirolactones.
K. Nickisch
,
D. Bittler
,
+5 authors
R. Wiechert
Journal of medicinal chemistry
1987
Corpus ID: 31975585
Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone were synthesized with the purpose of increasing the…
Expand
1986
1986
Mespirenone and other 15,16-methylene-17-spirolactones, a new type of steroidal aldosterone antagonists.
W. Losert
,
D. Bittler
,
+6 authors
R. Wiechert
Arzneimittel-Forschung
1986
Corpus ID: 19367004
The ability of a series of 15,16-methylene-spirolactones in comparison to known antimineralocorticoids to inhibit the renal…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
,
Terms of Service
, and
Dataset License
ACCEPT & CONTINUE