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mespirenone

Known as: 7alpha-acetylthio-15beta,16beta-methylene-3-oxo-17alpha-pregna-1,4-diene-21,17-carbolactone 
A spironolactone derivative and aldosterone antagonist with diuretic activity. Mespirenone, after in vivo metabolization, inhibits aldosterone… 
National Institutes of Health

Papers overview

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2001
2001
In humans, spironolactone and mespirenone are well known antimineralocorticoids without C-11beta substituents. These compounds… 
1999
1999
The potency of in vitro-added corticosteroids to stimulate electrogenic Na+absorption ( J Na, the Na+ absorptive short-circuit… 
1993
1993
Various steroidal 17-spirolactones substituted in the 11 beta-position were synthesized to study the relationship between the… 
1991
1991
The effects of the mineralocorticoid antagonist mespirenone on the development and maintenance of aldosterone-induced… 
1991
1991
Mespirenone (CAS 87952-98-5), the delta 1,2-15 beta, 16 beta-methylene derivative of spironolactone, proved to be a potent and… 
1989
1989
Previous studies have determined that mineralocorticoid hormones are able to increase the number of angiotensin II (ANG II… 
1987
1987
Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone were synthesized with the purpose of increasing the… 
1986
1986
The ability of a series of 15,16-methylene-spirolactones in comparison to known antimineralocorticoids to inhibit the renal…