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mespirenone

Known as: 7alpha-acetylthio-15beta,16beta-methylene-3-oxo-17alpha-pregna-1,4-diene-21,17-carbolactone 
A spironolactone derivative and aldosterone antagonist with diuretic activity. Mespirenone, after in vivo metabolization, inhibits aldosterone… 
National Institutes of Health

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2 relations

Broader (1)

Spironolactone
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Antimineralocorticoid 11beta-substituted spirolactones exhibit androgen receptor agonistic activity: a structure function study.
In humans, spironolactone and mespirenone are well known antimineralocorticoids without C-11beta substituents. These compounds… 
1994
1994
Development of specific bioluminescent In vitro assays for selecting potential antimineralocorticoids
1993
1993
Synthesis of new 11 beta-substituted spirolactone derivatives. Relationship with affinity for mineralocorticoid and glucocorticoid receptors.
Various steroidal 17-spirolactones substituted in the 11 beta-position were synthesized to study the relationship between the… 
1991
1991
Effect of a new mineralocorticoid antagonist mespirenone on aldosterone-induced hypertension.
The effects of the mineralocorticoid antagonist mespirenone on the development and maintenance of aldosterone-induced… 
1991
1991
Interference of C17-spirosteroids with late steps of aldosterone biosynthesis. Structure-activity studies.
Structure-activity relationships concerning the steroidal skeleton as well as the C21,17-ring systems could be established while… 
1989
1989
Modulation of angiotensin II binding sites in neuronal cultures by mineralocorticoids.
Previous studies have determined that mineralocorticoid hormones are able to increase the number of angiotensin II (ANG II… 
1988
1988
Experimental studies on the endocrine side effects of new aldosterone antagonists.
In the present study, endocrine-pharmacological profiles of new aldosterone antagonists, 15 beta,16 beta-methylenemexrenone (ZK… 
1987
1987
Aldosterone antagonists. 2. New 7 alpha-(acetylthio)-15,16-methylene spirolactones.
Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone were synthesized with the purpose of increasing the… 
1987
1987
Pharmacokinetics and metabolism of mespirenone, a new aldosterone antagonist, in rat and cynomolgus monkey.
The pharmacokinetics and metabolism of mespirenone were examined in rat and cynomolgus monkey using the tritiated drug. Following… 
1986
1986
Mespirenone and other 15,16-methylene-17-spirolactones, a new type of steroidal aldosterone antagonists.
The ability of a series of 15,16-methylene-spirolactones in comparison to known antimineralocorticoids to inhibit the renal… 
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