membrane protein ectodomain proteolysis

Known as: ectodomain cleavage 
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:jl, http://www.copewithcytokines.de/]
National Institutes of Health

Related topics

Related topics

4 relations
membrane protein solubilizationnegative regulation of membrane protein ectodomain proteolysispositive regulation of membrane protein ectodomain proteolysisreceptor shedding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids… (More)
Is this relevant?
2008
2008
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
β-Amyloid precursor protein (APP) has been reported to play a role in the outgrowth of neurites from cultured neurons. Both cell… (More)
Is this relevant?
Review
2007
Review
2007
Bidirectional Eph-ephrin signaling during axon guidance.
Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in trans on opposing cells. In the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2007
2007
Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding.
Ecto-phosphorylation is emerging as an important mechanism to regulate cellular ligand interactions and signal transduction. Here… (More)
Is this relevant?
2006
2006
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44.
Ectodomain shedding is a proteolytic mechanism by which transmembrane molecules are converted into a soluble form. Cleavage is… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2004
2004
Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors.
Soluble tumor necrosis factor receptors (TNFRs) are important modulators of TNF bioactivity. Proteolytic cleavage of the 28-kDa… (More)
Is this relevant?
2003
2003
Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23.
The ADAM family of disintegrin metalloproteases plays important roles in "ectodomain shedding," the process by which biologically… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells.
HER2 is a ligand-less tyrosine kinase receptor of the ErbB family that is frequently overexpressed in breast cancer. It undergoes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1.
The function of many transmembrane molecules can be altered by cleavage and subsequent release of their ectodomains. We have… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades.
A variety of transmembrane proteins, such as transforming growth factor-alpha (TGF-alpha), tumor necrosis factor-alpha (TNF-alpha… (More)
Is this relevant?