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membrane protein ectodomain proteolysis

Known as: ectodomain cleavage 
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:jl, http://www.copewithcytokines.de/]
National Institutes of Health

Related topics

Related topics

4 relations
membrane protein solubilizationnegative regulation of membrane protein ectodomain proteolysispositive regulation of membrane protein ectodomain proteolysisreceptor shedding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
ADAM17-Mediated Ectodomain Shedding of Toll-Like Receptor 4 as a Negative Feedback Regulation in Lipopolysaccharide-Activated Aortic Endothelial Cells
Background/Aims: Lipopolysaccharide (LPS)-activated monocytes/macrophages develop endotoxin tolerance in part by reducing cell… 
Highly Cited
2014
Highly Cited
2014
Inhibitory effects of oroxylin A on endothelial protein C receptor shedding in vitro and in vivo
Endothelial cell protein C receptor (EPCR) plays important roles in blood coagulation and inflammation. EPCR activity is markedly… 
2009
2009
KIT variants in bovine ovarian cells and corpus luteum
We report the presence of KIT variants in granulosa and thecal cells of the follicle and endothelial and steroidogenic cells of… 
Highly Cited
2008
Highly Cited
2008
TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer
Purpose: Activation of the epidermal growth factor receptor (EGFR) requires cell surface cleavage of EGFR ligands, uptake of… 
2007
2007
Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin
The thyrotropin receptor (TSHR) has a unique 50 residue (317–366) ectodomain insertion that sets it apart from other glycoprotein… 
2006
2006
ErbB-4 and TNF-alpha converting enzyme localization to membrane microdomains.
Sequential proteolytic processing of ErbB-4 occurs in response to ligand addition. Here, we assess the localization of cleavable… 
2004
2004
Canine Distemper Virus and Measles Virus Fusion Glycoprotein Trimers: Partial Membrane-Proximal Ectodomain Cleavage Enhances Function
ABSTRACT The trimeric fusion (F) glycoproteins of morbilliviruses are activated by furin cleavage of the precursor F0 into the F1… 
2001
2001
The Proamphiregulin Cytoplasmic Domain Is Required for Basolateral Sorting, but Is Not Essential for Constitutive or Stimulus-induced Processing in Polarized Madin-Darby Canine Kidney Cells*
In this study, the role of the amphiregulin precursor (pro-AR) cytoplasmic domain in the basolateral sorting and cell-surface… 
Review
2000
Review
2000
Tie-1 receptor tyrosine kinase endodomain interaction with SHP2: potential signalling mechanisms and roles in angiogenesis.
The endothelial receptor tyrosine kinase plays an essential role in vascular development where it is thought to be required for… 
1996
1996
Structural Requirements for the Ectodomain Cleavage of Human Cell Surface Macrophage Colony-stimulating Factor*
One form of human macrophage colony-stimulating factor (CSF-1256, M-CSFα) is a member of a restricted set of cell surface… 
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