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membrane protein ectodomain proteolysis
Known as:
ectodomain cleavage
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:jl, http://www.copewithcytokines.de/]
National Institutes of Health
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Related topics
Related topics
4 relations
membrane protein solubilization
negative regulation of membrane protein ectodomain proteolysis
positive regulation of membrane protein ectodomain proteolysis
receptor shedding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Inhibitory effects of oroxylin A on endothelial protein C receptor shedding in vitro and in vivo
S. Ku
,
Min‐Su Han
,
Min Young Lee
,
You-Mie Lee
,
J. Bae
BMB Reports
2014
Corpus ID: 11325180
Endothelial cell protein C receptor (EPCR) plays important roles in blood coagulation and inflammation. EPCR activity is markedly…
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Highly Cited
2008
Highly Cited
2008
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
T. Young-Pearse
,
Allen C. Chen
,
Rui Chang
,
Cesar Marquez
,
D. Selkoe
Neural Development
2008
Corpus ID: 6293526
Backgroundβ-Amyloid precursor protein (APP) has been reported to play a role in the outgrowth of neurites from cultured neurons…
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Highly Cited
2007
Highly Cited
2007
Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor*
C. Litterst
,
A. Georgakopoulos
,
+5 authors
N. Robakis
Journal of Biological Chemistry
2007
Corpus ID: 31350135
Binding of EphB receptors to ephrinB ligands on the surface of adjacent cells initiates signaling cascades that regulate…
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Highly Cited
2006
Highly Cited
2006
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44.
Alexander Stoeck
,
Sascha Keller
,
+7 authors
P. Altevogt
Biochemical Journal
2006
Corpus ID: 21180795
Ectodomain shedding is a proteolytic mechanism by which transmembrane molecules are converted into a soluble form. Cleavage is…
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Review
2005
Review
2005
L‐selectin: mechanisms and physiological significance of ectodomain cleavage
D. Smalley
,
K. Ley
Journal of Cellular and Molecular Medicine
2005
Corpus ID: 17707684
L‐selectin is a cell adhesion molecule consisting of a large, highly glycosylated, extracellular domain, a single spanning…
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Highly Cited
2004
Highly Cited
2004
Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors.
F. Hawari
,
Farshid N. Rouhani
,
+4 authors
S. Levine
Proceedings of the National Academy of Sciences…
2004
Corpus ID: 36231607
Soluble tumor necrosis factor receptors (TNFRs) are important modulators of TNF bioactivity. Proteolytic cleavage of the 28-kDa…
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Highly Cited
2003
Highly Cited
2003
Characterization of Growth Factor-induced Serine Phosphorylation of Tumor Necrosis Factor-α Converting Enzyme and of an Alternatively Translated Polypeptide*
Huizhou Fan
,
C. Turck
,
R. Derynck
Journal of Biological Chemistry
2003
Corpus ID: 38319017
Tumor necrosis factor-α converting enzyme (TACE) is a prototype member of the adamalysin family of transmembrane metalloproteases…
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Highly Cited
2003
Highly Cited
2003
Catalytic Activity of ADAM8, ADAM15, and MDC-L (ADAM28) on Synthetic Peptide Substrates and in Ectodomain Cleavage of CD23*
A. Fourie
,
F. Coles
,
Veronica Moreno
,
L. Karlsson
Journal of Biological Chemistry
2003
Corpus ID: 20815224
The ADAM family of disintegrin metalloproteases plays important roles in “ectodomain shedding,” the process by which biologically…
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Highly Cited
2000
Highly Cited
2000
Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death*
E. Coulson
,
K. Reid
,
+4 authors
P. Bartlett
Journal of Biological Chemistry
2000
Corpus ID: 987948
The cytoplasmic juxtamembrane region of the p75 neurotrophin receptor (p75NTR) has been found to be necessary and sufficient to…
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Highly Cited
1999
Highly Cited
1999
Ectodomain shedding of TGF‐α and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades
Huizhou Fan
,
R. Derynck
EMBO Journal
1999
Corpus ID: 29043748
A variety of transmembrane proteins, such as transforming growth factor‐α (TGF‐α), tumor necrosis factor‐α (TNF‐α) and L‐selectin…
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