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mdm2 protein

Known as: Proto Oncogene Proteins c mdm2, c mdm2 Proto Oncogene Protein, c-mdm2 Proto-Oncogene Protein 
An E3 UBIQUITIN LIGASE that interacts with and inhibits TUMOR SUPPRESSOR PROTEIN P53. Its ability to ubiquitinate p53 is regulated by TUMOR… 
National Institutes of Health

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In BloodProcess of secretionProtein Mdm4antagonists & inhibitors

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MDM2 protein, human

Papers overview

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2016
2016
Label-Free Real-Time Microarray Imaging of Cancer Protein-Protein Interactions and Their Inhibition by Small Molecules.
A rapid optical microarray imaging approach for anticancer drug screening at specific cancer protein-protein interface targets… 
2013
2013
3 MDM × 8 WDM × 320-Gb/s DP-32QAM transmission over a 120km few-mode fiber span employing 3-spot mode couplers
We verify three mode-division multiplexed×8 wavelength-division multiplexing×320-Gb/s DP-32QAM transmission over a 120km… 
2010
2010
Efficacy of MDM2 inhibitor MI-219 against lung cancer cells alone or in combination with MDM2 knockdown, a XIAP inhibitor or etoposide.
The p53 tumor suppressor is negatively regulated by murine double minute 2 (MDM2), which binds to p53 and promotes p53… 
2005
2005
Induction of p53 by Urokinase in Lung Epithelial Cells*
Urokinase plasminogen activator (uPA) is a serine protease that catalyzes the conversion of plasminogen to plasmin. The… 
2000
2000
TP53 mutations and mdm2 protein overexpression in cholangiocarcinomas.
Tumor suppressor protein p53 is a positive regulator of MDM2 gene expression and the mdm2 protein can bind to p53, preventing the… 
1999
1999
The pathway regulating MDM2 protein degradation can be altered in human leukemic cells.
The MDM2 protein regulates the functional activity of the p53 tumor suppressor through direct physical association. Signals that… 
1999
1999
Expression of mdm-2 oncoprotein in the primary and metastatic sites of mammary tumor (GI-101) implanted athymic nude mice.
The expression of mdm-2 oncoprotein (p90) was determined in a human breast tumor xenograft line (GI-101) that was derived from a… 
1999
1999
Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: prognostic significance
Abstract  TP53 and MDM2 genes and their protein expression were evaluated in frozen and paraffin-embedded tissue from 27 patients… 
Highly Cited
1997
Highly Cited
1997
Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia.
PURPOSE To determine whether potential alteration in p53 function through p53 gene mutation or mdm-2 overexpression correlates… 
1996
1996
mdm‐2 Oncogene Expression in Non‐Hodgkin's Lymphomas
The mdm-2 protein is a 90-kD protein that forms a complex with the p53 protein, enabling cells from some human neoplasms to… 
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