Protein Mdm4

Known as: MDM4, p53-Binding Protein Mdm4, Protein Mdmx 
Protein Mdm4 (490 aa, ~55 kDa) is encoded by the human MDM4 gene. This protein plays a role in the mediation of cell cycle arrest.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is… (More)
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Highly Cited
2007
Highly Cited
2007
The tumor suppressor p53 is inactivated by multiple mechanisms that include mutations of the p53 gene itself and increased levels… (More)
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Highly Cited
2006
Highly Cited
2006
The mechanisms by which Mdm2 and Mdm4 (MdmX) regulate p53 remain controversial. We generated a mouse encoding p53 lacking the… (More)
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Highly Cited
2006
Highly Cited
2006
The Mdm2 and Mdm4 oncoproteins are key negative regulators of the p53 tumor suppressor. However, their physiological… (More)
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Highly Cited
2006
Highly Cited
2006
Loss of Mdm2 or Mdm4 leads to embryo lethal phenotypes that are p53-dependent. To determine whether Mdm2 and Mdm4 inhibit p53… (More)
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Highly Cited
2006
Highly Cited
2006
The function of the p53 tumor suppressor to inhibit proliferation or initiate apoptosis is often abrogated in tumor cells. Mdm2… (More)
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Highly Cited
2004
Highly Cited
2004
Human tumors are believed to harbor a disabled p53 tumor suppressor pathway, either through direct mutation of the p53 gene or… (More)
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Highly Cited
2002
Highly Cited
2002
We report here the characterization of a mutant mouse line with a specific gene trap event in the Mdm4 locus. Absence of Mdm4… (More)
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Highly Cited
2001
Highly Cited
2001
The p53 protein can inhibit cell cycling or induce apoptosis, and is thus a critical regulator of tumorigenesis. This protein is… (More)
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Highly Cited
1999
Highly Cited
1999
We have previously reported on the amplification and overexpression of the MDM2 proto-oncogene in a subset of malignant gliomas… (More)
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