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marimastat

Known as: (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid, (2S,3R)-3-{(S)-[2,2-Dimethyl-1-(methylcarbamoyl) propyl]carbamoyl}-2-hydroxy-5-methylhexanohydroxamic acid, Marimistat 
An orally-active synthetic hydroxamate with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the active site of… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

BB-2516TA-2516

Broader (2)

Enzyme InhibitorsHydroxamic Acids
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors.
Highly Cited
2006
Highly Cited
2006
Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: A relationship among efficacy, joint toxicity and anticonvulsant status
PurposeSince anaplastic gliomas (AG) depend on matrix metalloproteinases for tumor cell invasion and angiogenesis, we undertook… 
Highly Cited
2005
Highly Cited
2005
Epidermal Growth Factor Receptor-Dependent and -Independent Pathways in Hydrogen Peroxide-Induced Mitogen-Activated Protein Kinase Activation in Cardiomyocytes and Heart Fibroblasts
Mild doses of oxidative stress in the heart correlate with the induction of apoptosis or hypertrophy in cardiomyocytes (CMCs) and… 
Review
2003
Review
2003
Angiogenesis inhibitors under study for the treatment of lung cancer.
Highly Cited
2002
Highly Cited
2002
Design, Synthesis, and Characterization of Potent, Slow-binding Inhibitors That Are Selective for Gelatinases*
Gelatinases have been shown to play a key role in angiogenesis and tumor metastasis. Small molecular weight synthetic inhibitors… 
2002
2002
Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of αvβ3 receptor blockade
Review
2001
Review
2001
Angiogenesis inhibitors in the treatment of lung cancer.
Review
2001
Review
2001
Alternatives to chemotherapy and radiotherapy in the treatment of small cell lung cancer.
Highly Cited
1998
Highly Cited
1998
Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon…
The solubilization of plasma membrane receptors through proteolytic cleavage of the ligand binding domain at the cell surface is… 
Review
1997
Review
1997
Alternatives to chemotherapy and radiotherapy as adjuvant treatment for lung cancer.
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