marimastat

Known as: (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid, (2S,3R)-3-{(S)-[2,2-Dimethyl-1-(methylcarbamoyl) propyl]carbamoyl}-2-hydroxy-5-methylhexanohydroxamic acid, Marimistat 
An orally-active synthetic hydroxamate with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the active site of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
PURPOSE To determine whether a matrix metalloproteinase inhibitor improves progression-free survival (PFS) in patients with… (More)
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Highly Cited
2002
Highly Cited
2002
Pancreatic cancer is the fifth most common cause of cancer death in the western world and the prognosis for unresectable disease… (More)
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Highly Cited
2002
Highly Cited
2002
This randomised, double-blind, placebo-controlled study was designed to evaluate the ability of the orally administered matrix… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE Novel therapies are needed for patients with recurrent glioblastoma multiforme (GBM). Because there is evidence that… (More)
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Highly Cited
2002
Highly Cited
2002
Of 14 chemokine receptors investigated, only CXCR4 was expressed on ovarian cancer cells [C. J. Scotton et al., Cancer Res., 61… (More)
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2002
2002
PURPOSE To assess the outcome of high central dose Gamma Knife radiosurgery plus marimastat in patients with recurrent malignant… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE The prognosis for unresectable pancreatic cancer remains dismal (1-year survival rate, < 10%; 5-year survival rate, < 5… (More)
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Review
2001
Review
2001
Angiogenesis is a fundamental process in reproduction and wound healing. Under these conditions, neovascularization is tightly… (More)
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Review
1999
Review
1999
Marimastat (BB-2516) is the first matrix metalloproteinase inhibitor to have entered clinical trials in the field of oncology. It… (More)
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Highly Cited
1998
Highly Cited
1998
This combined analysis investigated the effect of marimastat, a specific inhibitor of matrix metalloproteinases, on markers of… (More)
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