mannopeptimycin
National Institutes of Health
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The emergence of antibiotic resistant microorganisms has led to an increased need for the discovery and development of novel…
The international press acknowledges original research contributions from natural sciences only in rare cases. However, the story…
L-Enduracididine (L-End) is a nonproteinogenic amino acid found in a number of bioactive peptides, including the antibiotics…
In biological systems, methylation is most commonly performed by methyltransferases (MTs) using the electrophilic methyl source S…
The asymmetric synthesis of the nonproteinogenic amino acids (2S,3S,4'S)-beta-hydroxyenduracididine 3 and (2R,3S,4'S)-beta…
[structure: see text] The enantioselective synthesis of the C-4' acylated 1,4-alpha,alpha-manno,manno-disaccharide fragment of…
Mannopeptimycins α–ɛ, novel glycopeptides with activity against methicillin-resistant staphylococci and vancomycin-resistant…
ABSTRACT The naturally occurring mannopeptimycins (formerly AC98-1 through AC98-5) are a novel class of glycopeptide antibiotics…
ABSTRACT AC98-6446 is a novel semisynthetic cyclic glycopeptide antibiotic related to the natural product mannopeptimycin α (AC98…