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macrolide biosynthetic process

Known as: macrolide biosynthesis, macrolide synthesis, macrolide anabolism 
The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone… 
National Institutes of Health

Papers overview

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2016
2016
Polyene macrolide biosynthesis in streptomycetes and related bacteria: recent advances from genome sequencing and experimental studies
The polyene macrolide group includes important antifungal drugs, to which resistance does not arise readily. Chemical and… 
Highly Cited
2012
Highly Cited
2012
Mandelalides A-D, cytotoxic macrolides from a new Lissoclinum species of South African tunicate.
Mandelalides A-D are variously glycosylated, unusual polyketide macrolides isolated from a new species of Lissoclinum ascidian… 
2011
2011
Synthetic studies of the lichen macrolide lepranthin. Stereoselective synthesis of the diolide framework based on regioselective epoxide-opening reactions.
Stereoselective synthesis of the 16-membered diolide 27, a fully functionalized congener of lepranthin (1), is described. The… 
Review
2010
Review
2010
Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects
Polyketides comprise one of the major families of natural products. They are found in a wide variety of bacteria, fungi, and… 
Review
2009
Review
2009
Cholesterol oxidase: a model flavoprotein oxidase and a biotechnological tool
Cholesterol oxidase (ChOx), or 3b-hydroxysterol oxidase, is a bacterial, FAD-containing flavoprotein involved in the initial… 
2008
2008
Stereoselective synthesis of (-)-amphidinolide E.
The total synthesis of (-)-amphidinolide E was accomplished by following a synthetic scheme that incorporates the labile C2… 
2006
2006
Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis
Enoyl reductase (ER) domains in module 5 of nystatin and amphotericin polyketide synthase (PKS) are responsible for reduction of… 
Review
2005
Review
2005
Approaches to the synthesis of immunolides: selective immunomodulatory macrolides for cystic fibrosis.
The discovery of the clinical effectiveness of erythromycin and azithromycin in inflammatory airway diseases has inspired the… 
2002
2002
Oxabicyclo[3.2.1]octenes in organic synthesis: direct ring opening of oxabicyclo[3.2.1] ring systems with diisobutylaluminum hydride and a silyl ketene acetal--synthesis of the chiral C(19)-C(26) and…
[reaction: see text] An efficient strategy for transforming meso-oxabicyclo[3.2.1]octenone 1 into optically active intermediates… 
2000
2000
Synthetic studies of an 18-membered antitumor macrolide, tedanolide. 6. Synthesis of a key intermediate via a highly efficient macrolactonization of computer-aid designed seco-acid.
A stereoselective synthesis is described of the 18-membered lactone (2) via an efficient macrolactonization of the conformation… 
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