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Bacterial metabolism of long-chain n-alkanes
- A. Wentzel, T. Ellingsen, H. Kotlar, S. Zotchev, M. Throne-Holst
- BiologyApplied Microbiology and Biotechnology
- 3 August 2007
Recent advances in the understanding of bacterial metabolism of long-chain n-alkanes are summarized and bacterial strategies for accessing these highly hydrophobic substrates are presented, along with systems for their enzymatic degradation and conversion into products of potential industrial value.
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.
Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity
- H. Bredholt, Espen Fjærvik, G. Johnsen, S. Zotchev
- Biology, Environmental ScienceMarine drugs
- 23 January 2008
It is suggested that actinomycetes from marine sediments in Norwegian fjords can be potential sources for the discovery of novel anti-infective agents and strong antibiotic-producing potential among them.
Identification of Novel Genes Involved in Long-Chain n-Alkane Degradation by Acinetobacter sp. Strain DSM 17874
- M. Throne-Holst, A. Wentzel, T. Ellingsen, H. Kotlar, S. Zotchev
- Biology, EngineeringApplied and Environmental Microbiology
- 30 March 2007
A novel high-throughput screening method and the screening of a transposon mutant library are described to identify genes involved in the degradation of n-alkanes with C chain lengths longer than 20, which are solid at 30°C, the optimal growth temperature for Acinetobacter sp.
Rare actinomycete bacteria from the shallow water sediments of the Trondheim fjord, Norway: isolation, diversity and biological activity.
- Harald Bredholdt, O. Galatenko, Kerstin Engelhardt, E. Fjaervik, L. P. Terekhova, S. Zotchev
- BiologyEnvironmental microbiology
- 1 November 2007
The study of shallow water sediments of the Trondheim fjord confirms the significant biodiversity of actinobacteria in the Norwegian marine habitats, and their potential for producing biologically active compounds.
Minimum Information about a Biosynthetic Gene cluster.
This work proposes the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard, to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.
Production of a New Thiopeptide Antibiotic, TP-1161, by a Marine Nocardiopsis Species
The in vitro antibacterial activity of this thiopeptide, designated TP-1161, against a panel of bacterial strains was determined and structure elucidation revealed this compound to be a new thiOPEptide antibiotic with a rare aminoacetone moiety.
In Vivo Analysis of the Regulatory Genes in the Nystatin Biosynthetic Gene Cluster of Streptomyces noursei ATCC 11455 Reveals Their Differential Control Over Antibiotic Biosynthesis
Data from cross-complementation experiments showed that nysR genes could in some cases substitute for each other, suggesting a functional hierarchy of the regulators and implying a cascade-like mechanism of regulation of nystatin biosynthesis.
Polyene macrolide antibiotics and their applications in human therapy.
- S. Zotchev
- Medicine, BiologyCurrent medicinal chemistry
- 31 January 2003
Current views on the biosynthesis of polyene macrolides, their mode of action and structure-function relationship, as well as strategies used to overcome the toxicity problem are discussed in this review.
Natural products in drug discovery: advances and opportunities
Recent technological developments that are enabling natural product-based drug discovery are summarized, selected applications are highlighted and key opportunities are discussed.