macroautophagy

Known as: autophagy in response to cellular starvation, non-specific autophagy, starvation-induced autophagy 
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Selective macroautophagy is an important protective mechanism against diverse cellular stresses. In contrast to the well… (More)
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2015
2015
Autophagy is a major catabolic process responsible for the delivery of proteins and organelles to the lysosome/vacuole for… (More)
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2013
2013
The primary role of autophagy is adaption to starvation. However, increasing evidence suggests that autophagy inhibition also… (More)
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2013
2013
Mutations in the autophagy receptor OPTN/optineurin are associated with the pathogenesis of glaucoma and amyotrophic lateral… (More)
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Highly Cited
2010
Highly Cited
2010
Starvation-induced autophagosomes engulf cytosol and/or organelles and deliver them to lysosomes for degradation, thereby… (More)
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Highly Cited
2010
Highly Cited
2010
Autophagy is a highly regulated intracellular degradation process by which cells remove cytosolic long-lived proteins and damaged… (More)
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Highly Cited
2009
Highly Cited
2009
The Hsc/Hsp70 co-chaperones of the BAG (Bcl-2-associated athanogene) protein family are modulators of protein quality control. We… (More)
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Highly Cited
2008
Highly Cited
2008
Starvation induces autophagy to preserve cellular homeostasis in virtually all eukaryotic organisms. However, the mechanisms by… (More)
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Highly Cited
2007
Highly Cited
2007
The anti-apoptotic proteins Bcl-2 and Bcl-X(L) bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we… (More)
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Highly Cited
2005
Highly Cited
2005
During starvation-induced autophagy in mammals, autophagosomes form and fuse with lysosomes, leading to the degradation of the… (More)
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