lomeguatrib

 
National Institutes of Health

Papers overview

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2013
2013
  • Mehmet Taspinar, Seda Ilgaz, +7 authors Hasan Caglar Ugur
  • Tumor Biology
  • 2013
Temozolomide (TMZ) is commonly used in the treatment of glioblastoma (GBM). The MGMT repair enzyme (O6-methylguanine-DNA… Expand
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Highly Cited
2012
Highly Cited
2012
Glioblastoma multiforme is the most common aggressive adult primary tumour of the central nervous system. Treatment includes… Expand
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2011
2011
Background:The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) reverses the O6-methylguanine (O6-meG) lesion… Expand
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2010
2010
PURPOSE A major mechanism of resistance to chlorethylnitrosureas and methylating agents involves the DNA repair protein O(6… Expand
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2009
2009
We evaluated the pharmacodynamic effects of the O6-methylguanine-DNA methyltransferase (MGMT) inactivator lomeguatrib (LM) on… Expand
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2009
2009
Lomeguatrib, an O6-methylguanine-DNA methyltransferase inactivator, was evaluated in an extended dosing regimen with temozolomide… Expand
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Review
2007
Review
2007
Triazene compounds of clinical interest (i.e. dacarbazine and temozolomide) are a group of alkylating agents with similar… Expand
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2007
2007
PURPOSE To evaluate tumor response, pharmacodynamic effects, and safety of a combination of lomeguatrib (LM), an O6-methylguanine… Expand
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2007
2007
Previous studies indicated that dacarbazine and Temozolomide could be highly effective against refractory acute leukaemia. Their… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE A major mechanism of resistance to temozolomide involves the DNA repair protein O6-alkylguanine-DNA-alkyltransferase… Expand
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