lomeguatrib
National Institutes of Health
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Lomeguatrib or Patrin-2 has been formulated to work in combination with Temozolomide. It does so by blocking the action of ATase…
To evaluate the tumour response to lomeguatrib and temozolomide (TMZ) administered for 5 consecutive days every 4 weeks in…
3597 Background: MGMT is implicated in tumor resistance to O6-alkylating agents, since the protein repairs DNA damage before…
Chemotherapy, alongside radiotherapy and surgery remains the mainstay of treatment for many cancers. However as our understanding…
Retroviral-mediated delivery of the P140K mutant O-methylguanine-DNA methyltransferase (MGMT) into hematopoietic stem cells (HSC…