lomeguatrib
National Institutes of Health
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Background/Aim:Multiple Myeloma (MM), characterized by aberrant accumulation of terminally differentiated plasma cells in the…
Lomeguatrib or Patrin-2 has been formulated to work in combination with Temozolomide. It does so by blocking the action of ATase…
The treatment of anaplastic astrocytoma (AA) is controversial. New chemotherapeutic approaches are needed for AA treatment…
To evaluate the tumour response to lomeguatrib and temozolomide (TMZ) administered for 5 consecutive days every 4 weeks in…
3597 Background: MGMT is implicated in tumor resistance to O6-alkylating agents, since the protein repairs DNA damage before…
Retroviral-mediated delivery of the P140K mutant O-methylguanine-DNA methyltransferase (MGMT) into hematopoietic stem cells (HSC…
Chemotherapy, alongside radiotherapy and surgery remains the mainstay of treatment for many cancers. However as our understanding…
Resistance to O6-alkylating agents can be overcome by depletion of the DNA repair protein, O6-alkylguanine DNA alkyltransferase…
8016 Background: TheDNA repair enzyme O6-Alkylguanine Alkyltransferase (AGT) directly reverses the O6-methylguanine (O6-MeG) base…