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lisofylline

Known as: 1H-purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-, LSF, 1-(5'-hydroxyhexyl)-3,7-dimethylxanthine 
A drug that may protect healthy cells from chemotherapy and radiation without inhibiting the effects of these therapies on tumor cells.
National Institutes of Health

Related topics

Related topics

7 relations

Broader (5)

Anti-Inflammatory Agents, Non-SteroidalImmunologic AdjuvantsImmunosuppressive AgentsPentoxifylline

Narrower (1)

CT-1501R
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Acute sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone concentration.
Sleep deprivation induces acute inflammation and increased glucocorticosteroids in vertebrates, but effects from fragmented, or… 
Highly Cited
2013
Highly Cited
2013
A novel cobalt-free, CO2-stable, and reduction-tolerant dual-phase oxygen-permeable membrane.
A novel CO2-stable and reduction-tolerant Ce0.8Sm0.2O(2-δ)-La0.9Sr0.1FeO(3-δ) (SDC-LSF) dense dual-phase oxygen-permeable… 
Highly Cited
2012
Highly Cited
2012
The transcription factor LSF: a novel oncogene for hepatocellular carcinoma.
The transcription factor LSF (Late SV40 Factor), also known as TFCP2, belongs to the LSF/CP2 family related to Grainyhead family… 
Highly Cited
2009
Highly Cited
2009
Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme.
Angiotensin-converting enzyme 2 (ACE2) is a newly identified regulator of the renin-angiotensin system. This type I membrane… 
Highly Cited
2000
Highly Cited
2000
Self-administration of intravenous amphetamine is predicted by individual differences in sucrose feeding in rats
Abstract  Rationale: Previous studies have shown that individual differences in oral sucrose consumption are predictive of the… 
Highly Cited
2000
Highly Cited
2000
Inhibition of the mammalian transcription factor LSF induces S‐phase‐dependent apoptosis by downregulating thymidylate synthase expression
The thymidylate synthase (TS) gene, which is induced at the G1–S transition in growth‐stimulated cells, encodes an enzyme that is… 
Highly Cited
1998
Highly Cited
1998
LSF and NTF-1 Share a Conserved DNA Recognition Motif yet Require Different Oligomerization States to Form a Stable Protein-DNA Complex*
The mammalian transcription factor LSF (also known as CP2 and LBP-1c) binds as a homo-oligomer to directly repeated elements in… 
Highly Cited
1997
Highly Cited
1997
Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity.
The mammalian transcription factor LSF (CP2/LBP-1c) binds cellular promoters modulated by cell growth signals. We demonstrate… 
Highly Cited
1993
Highly Cited
1993
Light scatter in the normal young, elderly, and cataractous eye demonstrates little wavelength dependency.
The purpose of the study was to investigate whether light scatter in normal young, elderly, and cataractous eyes exhibits… 
Highly Cited
1990
Highly Cited
1990
Transcription factor LSF binds two variant bipartite sites within the SV40 late promoter.
The HeLa transcription factor LSF has been purified by heparin-agarose and DNA affinity chromatography, and its DNA binding and… 
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