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linsitinib

Known as: Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl, cis-, cis-3-(8-Amino-1-(2-Phenylquinolin-7-yl)Imidazo(1,5-A)Pyrazin-3-yl)-1-Methylcyclobutanol 
An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity… Expand
National Institutes of Health

Papers overview

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2018
2018
BACKGROUND Linsitinib, an oral, dual inhibitor of insulin-like growth factor-1 receptor and insulin receptor, in combination with… Expand
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2017
2017
Introduction: First‐line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor treatment of advanced non–small‐cell… Expand
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2016
2016
Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) mutation have benefited from… Expand
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2016
2016
Ewing's sarcoma is a rare and aggressive malignancy. In the present study, tumor from a patient with a Ewing's sarcoma with… Expand
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2016
2016
Many protein kinases are valid drug targets in oncology because they are key components of signal transduction pathways. The… Expand
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2016
2016
CONTEXT The TSH receptor (TSHR) is considered the main target of stimulatory autoantibodies in the pathogenesis of Graves… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Adrenocortical carcinoma is a rare, aggressive cancer for which few treatment options are available. Linsitinib (OSI… Expand
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2014
2014
10507 Background: Most GISTs have activating mutations of KIT/PDGFRA, with rare cases of B-RAF/RAS mutations. 15% of GIST in… Expand
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2014
2014
In this study we investigated the effect of linsitinib on the reversal of multidrug resistance (MDR) mediated by the… Expand
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1990
1990
Methane monooxygenase catalyzes the oxygenation of 1,1-dimethylcyclopropane in the presence of O2 and NADH to (1… Expand
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