linsitinib

Known as: Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl, cis-, cis-3-(8-Amino-1-(2-Phenylquinolin-7-yl)Imidazo(1,5-A)Pyrazin-3-yl)-1-Methylcyclobutanol 
An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2018
05101520122018

Papers overview

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2016
2016
PURPOSE Cross-talk between type I IGF receptor (IGF1R), insulin receptor (INSR), and epidermal growth factor receptor (EGFR… (More)
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2016
2016
Ewing's sarcoma is a rare and aggressive malignancy. In the present study, tumor from a patient with a Ewing's sarcoma with… (More)
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2016
2016
This study characterized the pharmacokinetics, mass balance, routes and extent of elimination, metabolites, and safety of a… (More)
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2016
2016
Many protein kinases are valid drug targets in oncology because they are key components of signal transduction pathways. The… (More)
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2016
2016
Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) mutation have benefited from… (More)
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2015
2015
BACKGROUND Adrenocortical carcinoma is a rare, aggressive cancer for which few treatment options are available. Linsitinib (OSI… (More)
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2015
2015
To investigate the effect of different concentrations of inhibitors rapamycin, saracatinib, linsitinib and JNJ-38877605 on PC-3… (More)
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2015
2015
Therapeutic interventions in the insulin-like growth factor receptor (IGF-1R) pathway were expected to provide clinical benefits… (More)
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2014
2014
In this study we investigated the effect of linsitinib on the reversal of multidrug resistance (MDR) mediated by the… (More)
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2014
2014
To determine the maximum tolerated dose (MTD) of the combination of linsitinib (OSI-906), a dual inhibitor of IGFR and IR… (More)
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