OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells.

@article{Rao2014OVA66IC,
  title={OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells.},
  author={Wei Rao and Haowen Li and Feifei Song and Renfeng Zhang and Qinqin Yin and Ying Wang and Yebin Xi and Hailiang Ge},
  journal={Carcinogenesis},
  year={2014},
  volume={35 7},
  pages={1573-81}
}
Ovarian cancer-associated antigen 66 (OVA66), also known as CML66 (GenBank Accession No. AF283301), was first identified in an ovarian carcinoma complementary DNA (cDNA) expression library and was shown to play a role in tumorigenesis. Here, we find that OVA66 influences tumorigenesis by regulating the type I insulin-like growth factor receptor (IGF-1R) signaling pathway. Stable knockdown of OVA66 in cancer cells attenuated phosphorylation of IGF-1R and extracellular signal-regulated kinase 1/2… CONTINUE READING
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