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lifarizine

Known as: 1-((2-(4-methylphenyl)-5-methyl)-1H-imidazol-4-ylmethyl)-4-diphenylmethylpiperazine, lyfarizine 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

ImidazolesPiperazines

Narrower (1)

RS 87476

Papers overview

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1998
1998
Focal cerebral ischemia in the mouse: hypothermia and rapid screening of drugs.
1996
1996
The Effects of Lifarizine in Acute Cerebral Infarction: A Pilot Safety Study
Background and Purpose: Lifarizine is a novel ion channel modulator which is neuroprotective in experimental global and focal… 
1996
1996
Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones
1 . The effects of lifarizine (RS‐87476) on intracellular Ca2+ rises and the release of glutamate from rat cerebrocortical… 
1995
1995
Neuroprotective profile of lifarizine (RS‐87476) in rat cerebrocortical neurones in culture
1 The ability of the neuroprotective agent, lifarizine (RS‐87476), to mitigate veratridine‐, cyanide‐ and glutamate‐induced… 
1995
1995
[3H]‐lifarizine, a high affinity probe for inactivated sodium channels
1 [3H]‐lifarizine bound saturably and reversibly to an apparently homogeneous class of high affinity sites in rat cerebrocortical… 
1995
1995
Reduction by lifarizine of the neuronal damage induced by cerebral ischaemia in rodents
1 The objective of this study was to evaluate the broad neurocytoprotective potential of the novel sodium‐calcium ion channel… 
1995
1995
Lifarizine: A Blocker of Inactivated Voltage‐dependent Sodium Channels and Calcium Channels with Cerebral Neuroprotective Action
1995
1995
Efficacy and tolerability of lifarizine in acute ischemic stroke. A pilot study. Lifarizine Study Group.
1994
1994
Block of human voltage‐sensitive Na+ currents in differentiated SH‐SY5Y cells by lifarizine
1 The ability of lifarizine (RS‐87476) to block human voltage‐sensitive Na+ channel currents was studied by use of whole cell… 
1993
1993
The effect of lifarizine (RS‐87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil
1 Unilateral ligation of the right common carotid artery in the anaesthetized gerbil for 3 h caused a 62.7% decrease in… 
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