levoleucovorin

Known as: S leucovorin, levo leucovorin, (6S)-Folinic acid 
The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Preoperative (neoadjuvant) chemotherapy and radiotherapy are more effective than similar postoperative treatment for… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in clinical… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Recent studies have revealed that the modified Glasgow Prognostic Score (mGPS), an inflammation-based prognostic score… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Adjuvant systemic chemotherapy administered after surgical resection of colorectal cancer metastases may reduce the risk… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The mechanism of action of 5-fluorouracil (5-FU) has been associated with inhibition of thymidylate synthase (TS) and… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE This randomized, 2 x 2 factorial study compared a semimonthly (LVFU2) with a monthly (FULV) regimen of fluorouracil and… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE To evaluate the impact of tumor response; tumor and nodal downstaging; and cTNM, yTNM (clinical stage after… (More)
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2000
2000
Adenocarcinomas of the pancreas and biliary tract are highly malignant neoplasms, which are found in the advanced stage… (More)
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Highly Cited
1997
Highly Cited
1997
PURPOSE Response rates to fluorouracil (5-FU)-based therapy remain low. As new, active agents are being tested, information… (More)
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