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levoleucovorin

Known as: S leucovorin, levo leucovorin, (6S)-Folinic acid 
The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (3)

AntidoteLeucovorinN(5)-Formyltetrahydrofolate

Narrower (3)

Elvorine, Isovorin, Levofolene, LevorinFusilevIsovorin
In BloodLevoleucovorin calciumProcess of secretionagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
A case of Takotsubo cardiomyopathy during 5-fluorouracil treatment for rectal adenocarcinoma.
A case of acute heart failure due to Takotsubo cardiomyopathy induced by 5-fluorouracil is described. Acute heart failure… 
2008
2008
Long-term results of a phase II trial of high-dose radiotherapy (60 Gy) and UFT/l-leucovorin in patients with non-resectable locally advanced rectal cancer (LARC)
Background. Preoperative radiochemotherapy is a cornerstone in patients with non- resectable locally advanced rectal cancer (LARC… 
Highly Cited
2006
Highly Cited
2006
Alternating versus continuous "FOLFIRI" in advanced colorectal cancer (ACC): A randomized "GISCAD" trial.
3505 Background: In ACC "FOLFIRI" is one of the standard regimens and is able to obtain about 40% response rate (RR) with an… 
2006
2006
Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer. A meta-analysis of two randomized trials.
3524 Background: Adjuvant systemic chemotherapy (CT) administered after resection of colorectal cancer (CRC) metastases (M) may… 
Highly Cited
2001
Highly Cited
2001
Treatment of inoperable and/or metastatic biliary tree carcinomas with single-agent gemcitabine or in combination with levofolinic acid and infusional fluorouracil: results of a multicenter phase II…
1998
1998
Treatment of patients with advanced gastric carcinoma with a 5‐fluorouracil‐based or a cisplatin‐based regimen
Although many drug combination therapies have been proposed, there is no standard therapy for patients with advanced gastric… 
1997
1997
Prospectively randomized North Central Cancer Treatment Group trial of intensive-course fluorouracil combined with the l-isomer of intravenous leucovorin, oral leucovorin, or intravenous leucovorin…
PURPOSE A three-arm randomized phase III trial in advanced colorectal cancer patients was designed to test whether substitution… 
1997
1997
Augmentation of the chemotherapeutic effectiveness of UFT, a combination of tegafur [1-(2-tetrahydrofuryl)-5-fluorouracil] with uracil, by oral l-leucovorin.
UFT, combination of tegafur [1-(2-tetrahydrofuryl)-5-fluorouracil] with uracil, is widely-used as an anti-neoplastic agent in… 
1996
1996
Treatment of advanced adenocarcinomas of the exocrine pancreas and the gallbladder with 5‐fluorouracil, high dose levofolinic acid and oral hydroxyurea on a weekly schedule: Results of a multicenter…
To date there is no established chemotherapeutic treatment for patients with unresectable locally advanced and/or metastatic… 
1992
1992
Biochemical modulation of fluorouracil with leucovorin and interferon: preclinical and clinical investigations.
Leucovorin and interferon are capable of modulating the cytotoxicity of fluorouracil (5-FU). Preclinical studies demonstrate that… 
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