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levoleucovorin

Known as: S leucovorin, levo leucovorin, (6S)-Folinic acid 
The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (3)

AntidoteLeucovorinN(5)-Formyltetrahydrofolate

Narrower (3)

Elvorine, Isovorin, Levofolene, LevorinFusilevIsovorin
In BloodLevoleucovorin calciumProcess of secretionagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Randomised phase III trial of adjuvant chemotherapy with oral uracil and tegafur plus leucovorin versus intravenous fluorouracil and levofolinate in patients with stage III colorectal cancer who have…
Highly Cited
2011
Highly Cited
2011
Intermittent versus continuous chemotherapy in advanced colorectal cancer: a randomised 'GISCAD' trial.
BACKGROUND In advanced colorectal cancer, chemotherapy is usually administered without pauses and until progression but patients… 
Highly Cited
2004
Highly Cited
2004
First-line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil/leucovorin (FOLFOXIRI): results of a phase II study with a simplified biweekly schedule.
BACKGROUND In a previous phase I-II study we demonstrated that the FOLFOXIRI regimen [irinotecan 125-175 mg/m2 day 1, oxaliplatin… 
Highly Cited
2004
Highly Cited
2004
High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report…
The aim of the present study was to evaluate the role of a weekly preoperative chemotherapy in locally advanced, unresectable… 
Highly Cited
2003
Highly Cited
2003
Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: results of a randomized trial.
PURPOSE This randomized, 2 x 2 factorial study compared a semimonthly (LVFU2) with a monthly (FULV) regimen of fluorouracil and… 
Review
2001
Review
2001
Irinotecan in the treatment of colorectal cancer: clinical overview.
PURPOSE AND METHODS For more than three decades, the therapeutic options for patients with advanced colorectal cancer have almost… 
Highly Cited
2001
Highly Cited
2001
Treatment of inoperable and/or metastatic biliary tree carcinomas with single-agent gemcitabine or in combination with levofolinic acid and infusional fluorouracil: results of a multicenter phase II…
Highly Cited
2000
Highly Cited
2000
Effects of 5-fluorouracil and leucovorin in the treatment of pancreatic-biliary tract adenocarcinomas.
Adenocarcinomas of the pancreas and biliary tract are highly malignant neoplasms, which are found in the advanced stage… 
Highly Cited
1997
Highly Cited
1997
Intensive weekly chemotherapy for advanced gastric cancer using fluorouracil, cisplatin, epi-doxorubicin, 6S-leucovorin, glutathione, and filgrastim: a report from the Italian Group for the Study of…
PURPOSE A multiinstitutional trial was performed to confirm the clinical activity, in terms of response rate and toxicity… 
Highly Cited
1987
Highly Cited
1987
Definitive combined modality therapy of carcinoma of the anus
Thirty patients with epidermoid carcinoma of the anus, ranging in age from 40 to 89 years, were treated with combined… 
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