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A history of cancer chemotherapy.
TLDR
Today, chemotherapy has changed as important molecular abnormalities are being used to screen for potential new drugs as well as for targeted treatments. Expand
Pharmacokinetically guided dose adjustment of 5-fluorouracil: a rational approach to improving therapeutic outcomes.
TLDR
The data on pharmacokinetically guided dose adjustment of 5-FU is reviewed and the potential of this approach to advance therapeutic outcomes is discussed, as well as recent advances in testing based on liquid chromatography-mass spectroscopy and a nanoparticle antibody-based immunoassay for 5-fu may now allow for routine monitoring of5-FU in clinical practice. Expand
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil.
TLDR
It is demonstrated that continuous exposure of human colon cancer cells to 5-FU leads to TS gene amplification and overexpression of TS protein with resultant development of fluoropyrimidine resistance. Expand
First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors and non-Hodgkin's lymphomas
TLDR
Copanlisib was well tolerated with a manageable safety profile, with anti-tumor activity in both advanced solid tumors and hematological malignancies, in patients with advancedsolid tumors or non-Hodgkin's lymphoma. Expand
Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.
TLDR
These studies suggest that translation of TS mRNA is controlled by its own protein end product, TS, in an autoregulatory manner. Expand
Protein Kinase D as a Potential Chemotherapeutic Target for Colorectal Cancer
TLDR
The studies show that PKD plays a significant role in mediating growth signaling in colorectal cancer and may represent a novel chemotherapeutic target for the treatment of coloreCTal cancer. Expand
N-acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro.
TLDR
In vitro study using human umbilical vein endothelial cells (HUVECs), and in vivo zebrafish angiogenesis model, confirmed the antiangiogenic activity of N-acetyl-COs was significantly stronger than the parent oligosaccharide, COs. Expand
Oncologist factors that influence referrals to subspecialty palliative care clinics.
TLDR
Raising awareness of ways in which subspecialty palliative care complements standard oncology care and developing ways for oncologists and palliatives care physicians to collaborate and integrate their respective skills may help. Expand
Therapeutic drug monitoring of 5-fluorouracil
TLDR
Dose adjustment of 5-FU is feasible, and PK-based dosing can significantly improve clinical outcomes by reducing toxicities and improving efficacy, there is growing evidence to show. Expand
Molecular heterogeneity and function of EWS-WT1 fusion transcripts in desmoplastic small round cell tumors.
TLDR
Evidence is presented that various EWS-WT1 proteins up-regulated EGR-1 promoter activity and that this up-regulation is specifically dependent upon the absence of the exon 9 KTS domain of WT1. Expand
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