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leukotriene-C4 synthase activity

Known as: LTC4 synthetase activity, (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming), leukotriene C4 synthetase activity 
Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). [EC:4.4.1.20, RHEA:17620]
National Institutes of Health

Papers overview

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2005
2005
Analysis of Human Multidrug Resistance Protein 1 (ABCC1) by Matrix-Assisted Laser Desorption Ionization/Time of Flight Mass Spectrometry: Toward Identification of Leukotriene C4 Binding Sites
Multidrug resistance in tumor cells may be caused by reduced drug accumulation resulting from expression of one or more proteins… 
2002
2002
Uncoupled regulation of leukotriene C4 synthase in platelets from aspirin‐intolerant asthmatics and healthy volunteers after aspirin treatment
Background We have reported that thromboxane A2 induces suppression of leukotriene (LT) C4 synthase activity in human platelets. 
1997
1997
Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells.
1994
1994
Abnormal leukotriene C4 released by unaffected jejunal mucosa in patients with inactive Crohn's disease.
The mucosal release of inflammatory mediators is enhanced in active inflammatory bowel disease. This study examines whether… 
Review
1989
Review
1989
[Cardiovascular effects of leukotrienes].
Leukotrienes are among the most potent lipid mediators of inflammation. Leukotriene B4 is one of the most potent endogenously… 
1988
1988
Effect of azelastine on bronchoconstriction induced by histamine and leukotriene C4 in patients with extrinsic asthma.
Azelastine, a new oral agent with antiallergic and antihistamine properties, has been shown to inhibit the effect of histamine… 
Highly Cited
1987
Highly Cited
1987
Purification of a new acidic glutathione S-transferase, GST-Yn1Yn1, with a high leukotriene-C4 synthase activity from rat brain.
A new acidic form of glutathione S-transferase (GST, pI 6.2) was purified from rat brain by S-hexylglutathione affinity… 
1986
1986
LTC4 ‘receptor’: its demonstration using airway and non-airway tissues
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