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A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
TLDR
The cloning of the complementary DNA encoding a cell-surface LTB4 receptor that is highly expressed in human leukocytes is reported, showing that L TB4 is a unique lipid mediator that interacts with both cell- surface and nuclear receptors.
Platelet-activating factor receptor.
TLDR
The human platelet-activating factor receptor gene exists as a single copy on chromosome 1 and two 5′-noncoding exons (Exon 1 and 2) has distinct transcription initiation sites and promoters which up-regulates the PAF receptor expression only tissues with transcript 2.
Hydroxyeicosanoids Bind to and Activate the Low Affinity Leukotriene B4 Receptor, BLT2*
TLDR
It is suggested that BLT2 functions as a low affinity receptor, with broader ligand specificity for various eicosanoids, and mediates distinct biological and pathophysiological roles from BLT1.
Prediction of Fluoroquinolone‐Induced Elevation in Serum Creatinine Levels: A Case of Drug–Endogenous Substance Interaction Involving the Inhibition of Renal Secretion
TLDR
DX‐619, at its therapeutic dose, is able to inhibit hOCT2, hMate1, and hMATE2‐K, leading to a significant inhibition of tubular secretion of creatinine and consequently to elevation of serum creatinines levels.
Cystathionine γ-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury*
TLDR
The results raise questions against the homocysteine-based etiology of CBS deficiency and the current newborn screening for homocysteinemia using Guthrie's method, which detects hypermethioninemia.
Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery.
TLDR
Results evaluating a preliminary model applied to the CYP3A substrate drugs midazolam, indinavir, saquinavir, and rifabutin suggest that the model may be useful for predicting in vivo intestinal metabolism from in vitro data.
Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2
TLDR
Investigating the role of cytosolic phospholipase A2 in ARDS found that disruption of the gene encoding cPLA2 significantly reduced pulmonary edema, PMN sequestration and deterioration of gas exchange caused by lipopolysaccharide and zymosan administration.
Identification of 9-Hydroxyoctadecadienoic Acid and Other Oxidized Free Fatty Acids as Ligands of the G Protein-coupled Receptor G2A*
TLDR
G2A is activated by oxidized free fatty acids produced by oxidation and subsequent hydrolysis of phosphatidylcholine or cholesteryl linoleate, indicating that G2A might have a biological role in diverse pathological conditions including atherosclerosis.
Cell-Specific Transcriptional Regulation of Human Leukotriene B4 Receptor Gene
TLDR
The genomic structure and a promoter analysis of the human BLT1 gene and the first example of “promoter in ORF” in higher eukaryotes are reported, with an emphasis on the mechanism of cell-specific transcription.
Edoxaban Transport via P-Glycoprotein Is a Key Factor for the Drug’s Disposition
TLDR
The results demonstrate that edoxaban is a substrate of P-glycoprotein but not of other major uptake transporters tested, and the risk of clinical drug–drug interactions due to any Edoxaban-related transporter inhibition seems to be negligible.
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