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letermovir

An orally bioavailable, non-nucleoside, 3,4-dihydroquinazolinyl acetic acid and inhibitor of the pUL56 subunit of the viral terminase complex of… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

AIC246

Narrower (1)

MK-8228

Papers overview

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2020
2020
CMV Viral Load Kinetics as Surrogate Endpoints for Antiviral Prophylaxis Trials
2019
2019
Effect of letermovir on levonorgestrel and ethinyl estradiol pharmacokinetics
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OBJECTIVE Letermovir is an inhibitor of the terminase complex of cytomegalovirus (CMV) used as prophylactic therapy in CMV… 
Review
2019
Review
2019
Real World Outcomes of Letermovir Prophylaxis in Unselected High Risk CMV Seropositive Hematopoietic Stem Cell Transplant Recipients
Introduction: Cytomegalovirus (CMV) is a leading cause of morbidity following allogenenic hematopoietic stem cell transplant… 
2019
2019
Caution Is Required before Recommending Wide Use of Letermovir as Salvage Therapy for Cytomegalovirus Diseases
Turner et al. recently reported the use of letermovir in 4 solid-organ transplant recipients with ganciclovir-resistant… 
Review
2018
Review
2018
Letermovir for the prevention of cytomegalovirus infection in adult cytomegalovirus-seropositive hematopoietic stem cell transplant recipients
ABSTRACT Introduction: Allogeneic hematopoietic cell transplants (allo-HCT) recipients are at the high-risk of reactivation of… 
2018
2018
Pre-engraftment cytomegalovirus DNAemia in allogeneic hematopoietic stem cell transplant recipients: incidence, risk factors, and clinical outcomes
To gauge the risk of delaying initiation of prophylaxis with letermovir from the time of donor infusion to prevent CMV infection… 
2017
2017
Drug Susceptibility and Replicative Capacity of Multidrug-Resistant Recombinant Human Cytomegalovirus Harboring Mutations in UL56 and UL54 Genes
ABSTRACT Letermovir is an investigational antiviral agent with a novel mechanism of action involving the viral terminase (pUL56… 
2015
2015
In Vitro Drug Combination Studies of Letermovir (AIC246, MK-8228) with Approved Anti-Human Cytomegalovirus (HCMV) and Anti-HIV Compounds in Inhibition of HCMV and HIV Replication
ABSTRACT Despite modern prevention and treatment strategies, human cytomegalovirus (HCMV) remains a common opportunistic pathogen… 
2014
2014
CMV prophylaxis in hematopoietic-cell transplantation.
2012
2012
Antiviral treatment of cytomegalovirus infection: an update
This editorial summarizes recent developments in the management of ganciclovir-resistant human cytomegalovirus (HCMV) infections… 
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