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lersivirine

Known as: 1,3-Benzenedicarbonitrile, 5-((3,5-Diethyl-1-(2-Hydroxyethyl)-1H-Pyrazol-4-yl)Oxy)-, 5-((3,5-Diethyl-1-(2-Hydroxyethyl)-1H-Pyrazol-4-yl)Oxy)Benzene-1,3-Dicarbonitrile 
A next-generation, pyrazole non-nucleoside reverse transcriptase inhibitor. Lersivirine retains activity against HIV viruses with mutations at… 
National Institutes of Health

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1 relation

Broader (1)

UK 453,061

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Efficacy and Safety of Lersivirine Versus Etravirine for the Treatment of HIV-1 Infection in Patients with Prior Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Use and Evidence of NNRTI…
Abstract Objective: To assess the efficacy and safety of lersivirine versus etravirine in patients with HIV-1 and prior non… 
Review
2012
Review
2012
The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance
The use of highly active antiretroviral therapy (HAART) involves combinations of drugs to achieve maximal virological response… 
2012
2012
Efficacy and safety of lersivirine (UK-453,061) versus efavirenz in antiretroviral treatment-naive HIV-1-infected patients: week 48 primary analysis results from an ongoing, multicenter, randomized…
OBJECTIVE A 96-week clinical study was planned to estimate the antiviral activity and safety of lersivirine in treatment-naive… 
2012
2012
Developmental toxicity study of lersivirine in mice.
Lersivirine is a second-generation nonnucleoside reverse transcriptase inhibitor undergoing clinical development for the… 
2012
2012
The Pharmacokinetics of Lersivirine (UK-453,061) and HIV-1 Protease Inhibitor Coadministration in Healthy Subjects
Objective:Lersivirine (UK-453,061) is a next-generation nonnucleoside reverse transcriptase inhibitor, active against wild-type… 
Review
2012
Review
2012
The HIV-1 non-nucleoside reverse transcriptase inhibitors (part V): capravirine and its analogues.
Capravirine (S-1153, AG1549), a 1,2,4,5-tetrasubstituted imidazole derivative, was firstly reported by the Shionogi company to… 
2012
2012
Effect of lersivirine co-administration on pharmacokinetics of methadone in healthy volunteers.
2011
2011
Comparison of the Non‐Nucleoside Reverse Transcriptase Inhibitor Lersivirine with its Pyrazole and Imidazole Isomers
Lersivirine is a potent non‐nucleoside reverse transcriptase inhibitor with exceptional mutant resilience. Here, we compare the… 
2010
2010
Gateways to clinical trials.
Alemtuzumab, Atomoxetine hydrochloride; BioMatrix Flex drug-eluting stent, Botulinum toxin type B, Brivaracetam, Cannabidiol… 
2010
2010
Safety and tolerability of lersivirine, a nonnucleoside reverse transcriptase inhibitor, during a 28-day, randomized, placebo-controlled, Phase I clinical study in healthy male volunteers.
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