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lersivirine

Known as: 1,3-Benzenedicarbonitrile, 5-((3,5-Diethyl-1-(2-Hydroxyethyl)-1H-Pyrazol-4-yl)Oxy)-, 5-((3,5-Diethyl-1-(2-Hydroxyethyl)-1H-Pyrazol-4-yl)Oxy)Benzene-1,3-Dicarbonitrile 
A next-generation, pyrazole non-nucleoside reverse transcriptase inhibitor. Lersivirine retains activity against HIV viruses with mutations at… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

UK 453,061

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Application of the Huisgen cycloaddition and 'click' reaction toward various 1,2,3-triazoles as HIV non-nucleoside reverse transcriptase inhibitors.
Highly Cited
2015
Highly Cited
2015
Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous… 
2013
2013
Efficacy and Safety of Lersivirine (UK-453,061) Versus Efavirenz in Antiretroviral Treatment–Naive HIV-1–Infected Patients: Week 48 Primary Analysis Results From an Ongoing, Multicenter, Randomized…
Objective:A 96-week clinical study was planned to estimate the antiviral activity and safety of lersivirine in treatment-naive… 
Review
2012
Review
2012
The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance
The use of highly active antiretroviral therapy (HAART) involves combinations of drugs to achieve maximal virological response… 
2012
2012
Efficacy and safety of lersivirine (UK-453,061) versus efavirenz in antiretroviral treatment-naive HIV-1-infected patients: week 48 primary analysis results from an ongoing, multicenter, randomized…
OBJECTIVE A 96-week clinical study was planned to estimate the antiviral activity and safety of lersivirine in treatment-naive… 
2012
2012
Energetics of mutation-induced changes in potency of lersivirine against HIV-1 reverse transcriptase.
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are key components of highly active antiretroviral therapy for the… 
2012
2012
Effect of Rifampin and Rifabutin on the Pharmacokinetics of Lersivirine and Effect of Lersivirine on the Pharmacokinetics of Rifabutin and 25-O-Desacetyl-Rifabutin in Healthy Subjects
ABSTRACT Lersivirine is a nonnucleoside reverse transcriptase inhibitor (NNRTI) with a unique resistance profile exhibiting… 
2011
2011
Comparison of the Non‐Nucleoside Reverse Transcriptase Inhibitor Lersivirine with its Pyrazole and Imidazole Isomers
Lersivirine is a potent non‐nucleoside reverse transcriptase inhibitor with exceptional mutant resilience. Here, we compare the… 
Highly Cited
2010
Highly Cited
2010
Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1
ABSTRACT The nonnucleoside reverse transcriptase inhibitors (NNRTIs) are key components of highly active antiretroviral therapy… 
2010
2010
Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor…
Lersivirine [UK-453,061, 5-((3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl)oxy)benzene-1,3-dicarbonitrile] is a next… 
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