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lerisetron

Known as: 1-Phenyl-Methyl-2-Piperazinyl-1H-Benzimidazole Hydrochloride, 1-benzyl-2-(1-piperazinyl)benzimidazole 
The hydrochloride salt of a 2-piperazinylbenzimidazole-derivative serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity. Lerisetron… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzimidazolesPiperidines

Narrower (1)

F-0930-RS2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Pharmacokinetic–Pharmacodynamic Modeling of the Hydroxy Lerisetron Metabolite L6-OH in Rats: An Integrated Parent–Metabolite Model
PurposeThe twofold aim of this study was to characterize in vivo in rats the pharmacokinetics (PK) and pharmacodynamics (PD) of… 
Review
2003
Review
2003
Lerisetron. FAES.
Lerisetron is a 5-hydroxytryptamine3 receptor antagonist under development by FAES Farma for the potential treatment of emesis… 
2003
2003
Age-Related Changes in Pharmacokinetics and Pharmacodynamics of Lerisetron in the Rat: A Population Pharmacokinetic Model
Background: The importance of studying the effects of age on the pharmacokinetics and pharmacodynamics of lerisetron – a new 5… 
2002
2002
BMC Biochemistry BioMed Central Research article BMC 32002, Biochemistry
  • 2002
  • Corpus ID: 1384050
2002
2002
Pharmacokinetics and pharmacological effect of lerisetron, a new 5-HT3 antagonist, in rats.
The pharmacokinetics of lerisetron, a novel 5HT(3) antagonist, are studied together with its efficacy in inhibiting the serotonin… 
2002
2002
Effects of Lerisetron, a New 5-HT3 Receptor Antagonist, on Ipecacuanha- induced Emesis in Healthy Volunteers
Summary The purpose of these studies was to evaluate the effect of lerisetron (1-phenyl-methyl-2-piperazinyl-1H-benzimidazole… 
2001
2001
Altered Disposition and Effect of Lerisetron in Rats with Elevated Alpha1-acid Glycoprotein Levels
AbstractPurpose. To examine the effect of changes in plasma α1-acid glycoprotein (AAG) levels on the pharmacokinetics (PK) and… 
1998
1998
Antiemetic effects of Lerisetron in radiation-induced emesis in the dog.
The 5-HT3 receptor antagonists are the most potent antiemetics known at present. Lerisetron is a new 5-HT3 receptor antagonist… 
1998
1998
Serum protein binding of lerisetron, a novel specific 5HT3 antagonist, in patients with cancer
Abstract The aim of this study was, (1) to characterize the serum protein binding of lerisetron, a new 5-hydroxytryptamine (5-HT3… 
Highly Cited
1997
Highly Cited
1997
New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation.
A series of 2-piperazinylbenzimidazole derivatives were prepared and evaluated as 5-HT3 receptor antagonists. Their 5-HT3… 
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