leptin

Known as: Obese Gene Product, Obesity Factor, Obese Protein 
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Bone remodelling, the mechanism by which vertebrates regulate bone mass, comprises two phases, namely resorption by osteoclasts… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Sleep duration may be an important regulator of body weight and metabolism. An association between short habitual… (More)
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Highly Cited
2004
Highly Cited
2004
In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of… (More)
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Highly Cited
2004
Highly Cited
2004
Ghrelin, a recently described endogenous ligand for the growth hormone secretagogue receptor (GHS-R), is produced by stomach… (More)
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Highly Cited
2002
Highly Cited
2002
Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and… (More)
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Review
2000
Review
2000
The discovery of leptin in the mid-1990s has focused attention on the role of proteins secreted by adipose tissue. Leptin has… (More)
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Highly Cited
2000
Highly Cited
2000
Obesity in humans and in rodents is usually associated with high circulating leptin levels and leptin resistance. To examine the… (More)
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Highly Cited
1999
Highly Cited
1999
Recent studies have reinforced the view that the lateral hypothalamic area (LHA) regulates food intake and body weight. We… (More)
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Review
1999
Review
1999
the hypothalamus. Examination of these lesions has shown them to be very large, but they all have in common extensive bilateral… (More)
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Highly Cited
1995
Highly Cited
1995
The regulation of body weight and composition involves input from genes1,2 and the environment3,4, demonstrated, for example, by… (More)
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