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leinamycin

National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Leinamycin is a structurally novel Streptomyces-derived natural product that displays very potent activity against various human… Expand
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Highly Cited
2008
Highly Cited
2008
Modular polyketide synthases (PKSs) are giant bacterial enzymes that synthesize many polyketides of therapeutic value. In… Expand
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2007
2007
Nonribosomal peptide natural products are biosynthesized from amino acid precursors by nonribosomal peptide synthetases (NRPSs… Expand
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Review
2006
Review
2006
  • C. Jacob
  • Natural product reports
  • 2006
  • Corpus ID: 501920
A range of sulfur-containing natural products from plants, fungi, bacteria and animals have recently been investigated to… Expand
Highly Cited
2004
Highly Cited
2004
A 135,638 bp DNA region that encompasses the leinamycin (LNM) biosynthetic gene cluster was sequenced from Streptomyces… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT Leinamycin (LNM), produced by Streptomyces atroolivaceus, is a thiazole-containing hybrid peptide-polyketide natural… Expand
2000
2000
  • S. Wu, A. Greer
  • The Journal of organic chemistry
  • 2000
  • Corpus ID: 40967389
We describe here a study on the intramolecular nonbonded 1, 5-sulfur-oxygen (S-O) interaction in the antitumor antibiotic… Expand
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Highly Cited
1997
Highly Cited
1997
The natural product leinamycin ( 1),1 thought to derive its antitumor activity through reactions with DNA, is of interest because… Expand
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Highly Cited
1990
Highly Cited
1990
Leinamycin is a recently discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. It preferentially… Expand
Highly Cited
1989
Highly Cited
1989
Leinamycin (DC 107) is newly discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. Five different… Expand
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