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Leinamycin is a structurally novel Streptomyces-derived natural product that displays very potent activity against various human… Expand Modular polyketide synthases (PKSs) are giant bacterial enzymes that synthesize many polyketides of therapeutic value. In… Expand Nonribosomal peptide natural products are biosynthesized from amino acid precursors by nonribosomal peptide synthetases (NRPSs… Expand A range of sulfur-containing natural products from plants, fungi, bacteria and animals have recently been investigated to… Expand A 135,638 bp DNA region that encompasses the leinamycin (LNM) biosynthetic gene cluster was sequenced from Streptomyces… Expand ABSTRACT Leinamycin (LNM), produced by Streptomyces atroolivaceus, is a thiazole-containing hybrid peptide-polyketide natural… Expand We describe here a study on the intramolecular nonbonded 1, 5-sulfur-oxygen (S-O) interaction in the antitumor antibiotic… Expand The natural product leinamycin ( 1),1 thought to derive its antitumor activity through reactions with DNA, is of interest because… Expand Leinamycin is a recently discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. It preferentially… Expand Leinamycin (DC 107) is newly discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. Five different… Expand