leinamycin
National Institutes of Health
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Leinamycin is a structurally novel Streptomyces-derived natural product that displays very potent activity against various human…
Nonribosomal peptide natural products are biosynthesized from amino acid precursors by nonribosomal peptide synthetases (NRPSs…
The reaction of the antitumor agent leinamycin with thiols converts this natural product into an episulfonium ion that alkylates…
Reaction with thiol converts the antitumor natural product leinamycin to an episulfonium ion that alkylates the N(7)-position of…
Reaction of thiols with the 1,2-dithiolan-3-one 1-oxide heterocycle found in leinamycin (1) results in the conversion of this…
Covalent modification of cellular DNA can have profound biological consequences and, therefore, the mechanisms by which small…
We describe here a study on the intramolecular nonbonded 1, 5-sulfur-oxygen (S-O) interaction in the antitumor antibiotic…
The natural product leinamycin ( 1),1 thought to derive its antitumor activity through reactions with DNA, is of interest because…
Leinamycin is a recently discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. It preferentially…