leinamycin

 
National Institutes of Health

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2010
2010
Leinamycin is a structurally novel Streptomyces-derived natural product that displays very potent activity against various human… (More)
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Highly Cited
2008
Highly Cited
2008
Modular polyketide synthases (PKSs) are giant bacterial enzymes that synthesize many polyketides of therapeutic value. In… (More)
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2007
2007
Nonribosomal peptide natural products are biosynthesized from amino acid precursors by nonribosomal peptide synthetases (NRPSs… (More)
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2004
2004
A 135,638 bp DNA region that encompasses the leinamycin (LNM) biosynthetic gene cluster was sequenced from Streptomyces… (More)
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2004
2004
The reaction of the antitumor agent leinamycin with thiols converts this natural product into an episulfonium ion that alkylates… (More)
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Highly Cited
2003
Highly Cited
2003
Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules, each of which minimally contains… (More)
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2003
2003
Reaction with thiol converts the antitumor natural product leinamycin to an episulfonium ion that alkylates the N(7)-position of… (More)
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2001
2001
Covalent modification of cellular DNA can have profound biological consequences and, therefore, the mechanisms by which small… (More)
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1990
1990
Leinamycin is a recently discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. It preferentially… (More)
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1989
1989
Leinamycin (DC 107) is newly discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. Five different… (More)
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