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legumain activity

OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds. [EC:3.4.22.34]
National Institutes of Health

Related topics

Related topics

1 relation
asparaginylendopeptidase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A protease‐responsive fluorescent probe for sensitive imaging of legumain activity in living tumor cells
Legumain, a lysosomal cysteine protease, is critical for pathological progression and has been found to play an important role in… 
2019
2019
Synthesis and evaluation of radioactive/fluorescent peptide probes for imaging of legumain activity.
2017
2017
Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells
The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhibitor cystatin C is… 
2014
2014
Simvastatin Inhibits Glucose Metabolism and Legumain Activity in Human Myotubes
Simvastatin, a HMG-CoA reductase inhibitor, is prescribed worldwide to patients with hypercholesterolemia. Although simvastatin… 
2014
2014
Correction: Simvastatin Inhibits Glucose Metabolism and Legumain Activity in Human Myotubes
Copyright: ß 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons… 
Highly Cited
2013
Highly Cited
2013
Functional imaging of legumain in cancer using a new quenched activity-based probe.
Legumain is a lysosomal cysteine protease whose biological function remains poorly defined. Legumain activity is up-regulated in… 
Highly Cited
2010
Highly Cited
2010
Cystatin E/M suppresses legumain activity and invasion of human melanoma
BackgroundHigh activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and… 
2008
2008
Regulation of legumain activity by cystatin M in various cell lines
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Highly Cited
1999
Highly Cited
1999
Inhibition of Mammalian Legumain by Some Cystatins Is Due to a Novel Second Reactive Site*
We have investigated the inhibition of the recently identified family C13 cysteine peptidase, pig legumain, by human cystatin C… 
1999
1999
Colorimetric and fluorimetric microplate assays for legumain and a staining reaction for detection of the enzyme after electrophoresis.
The cysteine endopeptidase legumain was recently discovered in mammalian cells, predominantly localized in the lysosomal system… 
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