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Involvement of CD14 and Toll-Like Receptors in Activation of Human Monocytes by Aspergillus fumigatus Hyphae
It is suggested that T cells, B cells, and monocytes are involved in the innate immune response to invasive fungal pathogens and that serum components are relevant for activation of monocytes by hyphae. Expand
Peptidoglycan and Lipoteichoic Acid from Staphylococcus aureus Induce Tumor Necrosis Factor Alpha, Interleukin 6 (IL-6), and IL-10 Production in Both T Cells and Monocytes in a Human Whole Blood Model
The data indicate that circulating T cells and monocytes contribute to cytokine production in sepsis caused by gram-positive bacteria. Expand
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
It is proposed that LTA from S. aureus triggers the release of cytokines during staphylococcal infections, and both monocytes and T cells contribute to cytokine production induced by LTA. Expand
Structure, function, and regulation of human cAMP-dependent protein kinases.
The existence of a number of anchoring proteins specific to either RIIalpha or RIIbeta, and which localize cAKII isozymes toward distinct substrates at defined subcellular loci, strongly supports the idea that specific functions can be assigned to the various cAK isoz enzymes. Expand
Nuclear Legumain Activity in Colorectal Cancer
In similarity with previous studies on nuclear variants of related cysteine proteases, legumain was shown to process histone H3.1. Expand
Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes.
RI alpha-RI beta heterodimers complexed with the catalytic subunit represent a novel isozyme of cAKI (RI alpha RI beta C2), which enhances the possibilities for diversification of cAMP-mediated effects. Expand
The Human Gene for the Regulatory Subunit RIα of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase: Two Distinct Promoters Provide Differential Regulation of Alternately Spliced Messenger
The present study reports the exon-intron organization of the human RIα gene of cAMP-dependent protein kinase and approximately 2 kilobases (kb) of the 5′-flanking region obtained by isolation andExpand
Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95.
The results show a distinct redistribution of AKAP95 during mitosis, suggesting that the interaction between AKAP 95 and RIIalpha may be cell cycle-dependent. Expand
Chronic hyperglycaemia promotes lipogenesis and triacylglycerol accumulation in human skeletal muscle cells
Chronic hyperglycaemia increased triacylglycerol accumulation and the incorporation of carbohydrate into Triacyl glycerol concomitantly with a reduced insulin-stimulated glucose uptake and glycogen synthesis with enhanced acyl-CoA:1,2-diacyl Glycerol acyltransferase 1 activity. Expand
Sirolimus Interferes with the Innate Response to Bacterial Products in Human Whole Blood by Attenuation of IL‐10 Production
  • P. Jørgensen, J. E. Wang, +6 authors A. Aasen
  • Biology, Medicine
  • Scandinavian journal of immunology
  • 1 February 2001
It is postulate that the clinical use of the sirolimus may be associated with a dysregulated innate immune response to bacterial infection and thus an increased risk of hyperinflammation and sepsis. Expand