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Reassessment of diethylenetriaminepentaacetic acid (DTPA) as a chelating agent for indium-111 labeling of polypeptides using a newly synthesized monoreactive DTPA derivative.
It is indicated that MDTPA and its precursor, the tetra-tert-butyl derivative of DTPA, would be useful BCAs for 111In radiolabeling of polypeptides that have rapid blood clearance with high specific activities.
Enhancement of binding affinity for amyloid aggregates by multivalent interactions of 99mTc-hydroxamamide complexes.
The preliminary results suggest that a new molecular design based on bivalent (99m)Tc-Ham complexes may be reasonable to develop an imaging probe targeting amyloid aggregates, as reflected in the results of the inhibition assay.
99mTc-labeled mannosyl-neoglycoalbumin for sentinel lymph node identification.
Intracellular metabolic fate of radioactivity after injection of technetium-99m-labeled hydrazino nicotinamide derivatized proteins.
The findings in this study suggested that the development of appropriate co-ligands capable of preserving stable bonding with the Tc center is essential to reduce the residence time of radioactivity in nontarget tissues after administration of [99mTc]HYNIC-labeled proteins and peptides.
Albumin-mediated selenium transfer by a selenotrisulfide relay mechanism.
The HSA-mediated selenium transfer from the RBC treated with selenite to the hepatocytes involves a relay mechanism of thiol exchange that occurs between the selenotrisulfide and thiol compounds.
Recovery of uranium from seawater. X: Pore structure and uranium adsorption of macroreticular chelating resin containing amidoxime groups
Eight types of amidoxime–type resin (RNH) were derived from macroreticular acrylonitrile—divinylbenzene copolymer beads, which were synthesized by varying the amount of polymerization initiator.
Development of PET and SPECT Probes for Glutamate Receptors
Current progress towards the development of PET and SPECT probes for GluRs is reviewed, finding several PET ligands for mGluRs have been successfully employed in clinical studies.